Evidence map›Paper›PMID 39957508›Full record

SynthesisPsychological medicine2025

Psychological interventions for preventing relapse in individuals with partial remission of depression: a systematic review and individual participant data meta-analysis.

Joost Gülpen, Josefien J F Breedvelt, Eva A M van Dis, Gert J Geurtsen, Fiona C Warren, Cornelis van Heeringen, Caitlin Hitchcock, Fredrik Holländare, Marloes J Huijbers, Robin B Jarrett and 10 more

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Joost GülpenAmsterdam UMC, location University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.ORCID 0009-0008-1373-9820
Josefien J F BreedveltCentre for Urban Mental Health, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-1864-1861
Eva A M van DisAmsterdam UMC, location University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.ORCID 0000-0002-7727-3934
Gert J GeurtsenAmsterdam Neuroscience Research Institute, Amsterdam, The Netherlands.
Fiona C WarrenExeter Collaboration for Academic Primary Care (APEx), University of Exeter, Exeter, UK.
Cornelis van HeeringenDepartment of Head and Skin, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium.
Caitlin HitchcockMedical Research Council Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Fredrik HolländareDepartment of Psychiatry, School of Medical Sciences, Örebro University, Örebro, Sweden.ORCID 0000-0001-9500-7763
Marloes J HuijbersDepartment of Psychiatry, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
Robin B JarrettUniversity of Texas Southwestern Medical Center, Department of Psychiatry, Dallas, Texas, USA.ORCID 0000-0002-3634-0387
Françoise JermannDepartment of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.ORCID 0000-0001-6262-9603
Margo de JongeArkin Mental Health Institute, Amsterdam, The Netherlands.ORCID 0000-0002-5144-1119
Daniel N KleinDepartment of Psychology, Stony Brook University, Stony Brook, New York, USA.
Nicola S KleinGGZ Drenthe Mental Health Institute, Department Traumacentre, Beilen, The Netherlands.
S Helen MaHong Kong Centre for Mindfulness, Hong Kong, China.
Michael T MooreGordon F. Derner School of Psychology, Adelphi University, Garden City, New York, USA.
Damiaan A J P DenysAmsterdam UMC, location University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.ORCID 0000-0002-3191-3844
J Mark G WilliamsDepartment of Psychiatry, University of Oxford, Oxford, UK.
Willem KuykenDepartment of Psychiatry, University of Oxford, Oxford, UK.ORCID 0000-0002-8596-5252
Claudi L BocktingAmsterdam UMC, location University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Partial remission after major depressive disorder (MDD) is common and a robust predictor of relapse. However, it remains unclear to which extent preventive psychological interventions reduce depressive symptomatology and relapse risk after partial remission. We aimed to identify variables predicting relapse and to determine whether, and for whom, psychological interventions are effective in preventing relapse, reducing (residual) depressive symptoms, and increasing quality of life among individuals in partial remission. This preregistered (CRD42023463468) systematic review and individual participant data meta-analysis (IPD-MA) pooled data from 16 randomized controlled trials (

Indexed as

Major Depressive DisorderPsychosocial InterventionSecondary PreventionHumansQuality of LifeRandomized Controlled Trials as TopicRecurrenceDepressionIndividual participant data meta-analysisMajor depressive disorderMood disorderPartial remissionPsychological interventionsQuality of lifeRelapse preventionResidual symptomsTreatment

Identifiers

PMID39957508
PMCPMC12080647

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.