ArticleJournal of the American Chemical Society2025
Three-Coordinate Iron(0) Complex-Catalyzed Regioselective C-H Alkylation of Indole Derivatives.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Enantioselective Rh-catalyzed addition of indoles to enones and the key role of the free N-H group with acyclic enones.Chemical science · 2026Article
- Synthesis, crystal structure and DFT study of carbon-yl[3-(dibenzo[Acta crystallographica. Section E, Crystallographic communications · 2026Article
- Mechanochemical ligand-controlled regiodivergent hydroarylation of alkenes via iron-catalyzed C-H activation.Nature communications · 2025Article
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5 authors.
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Abstract
The synthesis of alkylated indoles, which are key intermediates for various drugs and bioactive molecules, is of great importance. However, most reports on the synthesis of functionalized indoles use toxic and expensive 4d or 5d metal catalysts, limiting the further application of these methods. Herein, we disclose a versatile regioselective C-H alkylation of indole derivatives using a well-defined three-coordinate iron(0) complex. Neither Grignard reagents nor additional additives are required, making the reaction sustainable, environmentally friendly, and compatible with a broad variety of functional groups to afford C2-alkylated indoles in high yields. In addition, by variation of the aryl substituent on the alkene substrate to the trisubstituted silyl group, the regioselectivity of the C-H alkylation can be altered from Markovnikov to
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