Evidence map›Paper›PMID 39957311›Full record

ArticleNeuro-oncology2025

Unveiling spatial heterogeneity in medulloblastoma: A multi-omics analysis of cellular state and geographical organization.

Jiankang Li, Hailong Liu, Ziwei Wang, Jiao Zhang, Xuan Chen, Craig Daniels, Xiaochong Wu, Olivier Saulnier, Hiromichi Suzuki, Pasqualino De Antonellis and 38 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

48 authors.

Jiankang LiBGI Research, Chongqing, China.
Hailong LiuChinese Institute for Medical Research, Beijing, China.ORCID 0000-0002-6181-2577
Ziwei WangBGI Research, Chongqing, China.
Jiao ZhangThe Arthur and Sonia Labatt Brain Tumor Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Xuan ChenCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Craig DanielsThe Arthur and Sonia Labatt Brain Tumor Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Xiaochong WuThe Arthur and Sonia Labatt Brain Tumor Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Olivier SaulnierCancer Heterogeneity Instability and Plasticity, Institute Curie, PSL University, Paris, France.
Hiromichi SuzukiDivision of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.
Pasqualino De AntonellisDepartment of Molecular Medicine and Medical Biotechnologies (DMMBM), "Federico II" University of Naples, Naples, Italy.
Alexandra RasnitsynDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Winnie OngDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Evan Y WangDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Liam D HendrikseDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Yu SuSchool of Public Health, Capital Medical University, Beijing, China.
Yu TianSchool of Public Health, Capital Medical University, Beijing, China.
Dongming HanCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Ruohan WangDepartment of Computer Science, City University of Hong Kong, Hong Kong.ORCID 0000-0003-2327-2888
Jialin MoKey Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fei LiuDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Kaiwen DengDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dongyang WangDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhaoyang FengDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yifei JiangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Yanong LiDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yuting MaBGI Research, Chongqing, China.
Zijia LiuCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Meiyu LiCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Peiyi TianCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Yanfeng ShiChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yong JiangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Tao YangChina National Gene Bank, BGI-Research, Shenzhen, Guangdong, China.
Shouwei LiDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Jianfeng LiangDepartment of Neurosurgery, Peking University International Hospital, Beijing, China.
Jingchuan WuDepartment of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Ying WangBeijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Wanjing ZouBeijing Neurosurgical Institute, Beijing, China.
Yina JiangDepartment of Pathology, the First Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, Shanxi, China.
Lusheng WangDepartment of Computer Science, City University of Hong Kong, Hong Kong.ORCID 0000-0002-4344-8791
Fang ChenBGI Research, Chongqing, China.
Xin JinBGI Research, Chongqing, China.ORCID 0000-0001-7554-4975
Shuaicheng LiDepartment of Computer Science, City University of Hong Kong, Hong Kong.ORCID 0000-0002-9723-1416
Xiaoguang QiuDepartment of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Chunde LiDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Ya GaoBGI Research, Chongqing, China.
Yujie TangKey Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine, Department of Histoembryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Michael D TaylorThe Arthur and Sonia Labatt Brain Tumor Research Centre and the Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Tao JiangChina National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-8529-4487

Funding

Beijing Nova Star Program 20220484058Capital Medical University Fund for Excellent Young Scholars 23KCB004National Key Research and Development Program of China 2022ZD0210100National Natural Science Foundation of China 81902975National Natural Science Foundation of China 81973531National Natural Science Foundation of China 82101356National Natural Science Foundation of China 82172608National Natural Science Foundation of China 82273343National Science Fund of Beijing for Distinguished Young Scholars 24JQG011Natural Science Foundation of Beijing Municipality L232079
6 · The paper itself

Abstract

backgroundDespite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear.

methodsWe analyze single-nucleus and spatial transcriptomes and chromatin accessibility from human MB spanning four subgroups, to identify malignant cell populations and describe the spatial evolutionary trajectories. The spatial copy number variations (CNVs) patterns and niches were analyzed to investigate the cellular interactions.

resultsThree main malignant cell populations were identified, including progenitor-like, cycling, and differentiated populations. Gene signatures of cell populations strongly correlate to clinical outcomes. These tumor cell populations are geographically organized as stem-like and mature regions, highlighting their spatially heterogeneous nature. Progenitor-like and cycling cells are mainly concentrated in stem-like regions, whereas various differentiated populations are primarily distributed in mature regions. By analyzing chromosomal alterations, we find that stem-like regions typically harbor a single pattern of CNVs, reflecting high originality and uniformity, which is in stark contrast to mature regions exhibiting multiple patterns with a broader range of biological functions. Projecting cellular state programs onto spatial sections fully illustrates the evolution from stem-like regions to various functional zones in mature regions, which is correlated to microenvironmental components along the paths to maintain stemness or promote differentiation.

conclusionsThis multi-omics database comprehensively facilitates the understanding of MB spatial evolutionary organization.

Indexed as

Biomarkers, TumorCerebellar NeoplasmsDNA Copy Number VariationsMedulloblastomaNeoplastic Stem CellsTranscriptomeGene Expression ProfilingGenetic HeterogeneityGenomicsHumansMultiomicsBiomarkers, Tumorcellular state programmedulloblastomaspatial organizationtrajectorial transition

Identifiers

PMID39957311
PMCPMC13223746

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.