Evidence map›Paper›PMID 39957301›Full record

ArticleEuropean journal of neurology2025

Tau PET Imaging With [

Thomas Gérard, Lise Colmant, Vincent Malotaux, Yasmine Salman, Lara Huyghe, Lisa Quenon, Emilien Boyer, Laurence Dricot, Adrian Ivanoiu, Renaud Lhommel and 1 more

Abstract read
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Olfactory decline tracks central-to-peripheral spread of tau pathology in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Review
  5. Review
  6. Synthesis and Evaluation of Radioiodinated [Journal of labelled compounds & radiopharmaceuticals · 2026
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thomas GérardNuclear Medicine Department, Cliniques Universitaires Saint Luc, Brussels, Belgium.ORCID 0000-0001-7997-3945
Lise ColmantInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0009-0006-6511-0819
Vincent MalotauxInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0000-0003-0737-9220
Yasmine SalmanInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-8564-5136
Lara HuygheInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0009-0009-3568-3474
Lisa QuenonInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0000-0001-9139-2422
Emilien BoyerInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0009-0009-6222-4580
Laurence DricotInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-8613-2420
Adrian IvanoiuInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.
Renaud LhommelNuclear Medicine Department, Cliniques Universitaires Saint Luc, Brussels, Belgium.ORCID 0000-0003-0668-6122
Bernard HanseeuwInstitute of Neurosciences, Université Catholique de Louvain, Brussels, Belgium.ORCID 0000-0002-3102-6778

Funding

Fonds de la Recherche Scientifique - FNRS 40011675StopAlzheimer Foundation 20210026WelBio 40010035
6 · The paper itself

Abstract

introductionSecond-generation tau-PET tracers like [

methodsParticipants were assigned to exclusive categorical diagnoses based on their amyloid (Aβ) and cognitive status. We quantified mesiotemporal (MTL) and neocortical [

resultsAmong the 28 Aβ- impaired subjects, only five presented significant and isolated mesiotemporal signal, most of them being suspected of primary age-related tauopathy (PART). Only two Aβ- impaired patients (7%) presented positive neocortical signal, both being diagnosed with fronto-temporal degeneration (FTD). The Tau-PET results of all the remaining Aβ- patients were comparable to the CU population, including eight other FTD patients. Importantly, 4R-only tauopathies (CBD and PSP) and sv-PPA were negative.

conclusion[

Indexed as

Alzheimer DiseaseBrainPositron-Emission TomographyTauopathiestau ProteinsAgedAged, 80 and overCognitive DysfunctionFemaleFluorine RadioisotopesHumansIsoquinolinesMaleMiddle AgedRadiopharmaceuticalsSensitivity and SpecificityFluorine RadioisotopesIsoquinolinesMK-6240Radiopharmaceuticalstau ProteinsAlzheimer's diseaseMK‐6240neurodegenerative diseasestauopathyTau PET

Identifiers

PMID39957301
PMCPMC11831001

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.