Evidence map›Paper›PMID 39957192›Full record

ArticleJournal of Parkinson's disease2024

Shachar Shani, Mali Gana-Weisz, Anat Bar-Shira, Avner Thaler, Tanya Gurevich, Anat Mirelman, Nir Giladi, Roy N Alcalay, Avi Orr-Urtreger, Orly Goldstein

Abstract read
In one paragraph

Article in Journal of Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shachar ShaniFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-2188-4514
Mali Gana-WeiszThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Anat Bar-ShiraThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Avner ThalerFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Tanya GurevichFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Anat MirelmanFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-1520-2292
Nir GiladiFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0003-1482-8522
Roy N AlcalayFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.ORCID 0000-0002-5717-4875
Avi Orr-UrtregerFaculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Orly GoldsteinThe Laboratory of Biomarkers and Genomics of Neurodegeneration, Neurological Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.ORCID 0000-0001-7781-2734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe adaptive immune response has a role in Parkinson's disease (PD). Patients with

objectiveTo evaluate the involvement of adaptive immune response genes in three PD groups:

methodsDifferentially expressed genes (DEGs) associated with PD were identified using four datasets. Of them, adaptive immune response genes were evaluated using whole-genome-sequencing of 201 unrelated Ashkenazi-Jewish (AJ) PD patients. Potential pathogenic variants were identified, and

resultsOf the four adaptive immune DEGs identified,

conclusionsCommon variants within

Indexed as

Adaptive ImmunityGenetic Predisposition to DiseaseParkinson DiseaseReceptors, Purinergic P2X7AdultAgedAge of OnsetFemaleHumansJewsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2MaleMiddle AgedLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LRRK2 protein, humanP2RX7 protein, humanReceptors, Purinergic P2X7adaptive immune responseGBA1LRRK2P2RX7Parkinson's disease

Identifiers

PMID39957192
PMCPMC13348328

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.