Evidence map›Paper›PMID 39957158›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Antidepressive and anxiolytic effects of a combination of Saffron and Chamomile in rats and their relationship with serotonin using methods.

Faiq Amin, Saara Ahmad, Muhammad Wasim, Asra Khan, Fazal Manzoor Arain, Zehra Batool, Saiqa Tabassum, Saima Khaliq, Noreen Samad, Saida Haider

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Intranasal essential oils in therapy: advances in clinical applications and delivery mechanisms.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Faiq AminDepartment of Biological and Biomedical Sciences, the Aga Khan University, Karachi 74800, Pakistan.
Saara AhmadDepartment of Biological and Biomedical Sciences, the Aga Khan University, Karachi 74800, Pakistan.
Muhammad WasimMaternal and Children's Health Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, China.
Asra KhanDepartment of Biological and Biomedical Sciences, the Aga Khan University, Karachi 74800, Pakistan.
Fazal Manzoor ArainDepartment of Biological and Biomedical Sciences, the Aga Khan University, Karachi 74800, Pakistan.
Zehra BatoolDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 74800, Pakistan.
Saiqa TabassumDepartment of Biosciences, Shaheed Zulfikar Ali Bhutto Institute of Science and Technology, Karachi 74800, Pakistan.
Saima KhaliqDepartment of Biochemistry, Federal Urdu University of Science, Arts and Technology, Karachi 74800, Pakistan.
Noreen SamadDepartment of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.
Saida HaiderDepartment of Biochemistry, University of Karachi, Karachi 74800, Pakistan.

Funding

Aga Khan University Dean's Startup Fund, Role of Natural Remedies on Psycho-neurological Deficits in Murine Model as Preclinical Studies Associated with or without Diabetes 2017-2021The Higher Education Commission, Islamabad, Pakistan 9447/Sindh/NRPU/R & D/HEC/2017
6 · The paper itself

Abstract

objectiveTo explore the potential of combining natural herbs like chamomile and saffron for the management of anxiety and depression.

methodsA rodent model of Major Depressive Disorder (MDD) and anxiety, secondary to streptozotocin-induced diabetes mellitus was made. A total of 6 rat groups were chosen; healthy and diseased controls; and diseased test groups of fluoxetine, saffron, chamomile, and combined saffron and chamomile treated (

resultsThe combined herbal treatment group showed significantly better (

conclusionThis study shows that in comparison to treatment with a SSRI, and individual herbs, the combination of chamomile and saffron showed overall improved outcomes.

Indexed as

Anti-Anxiety AgentsAntidepressive AgentsAnxietyChamomileCrocusDepressionDrugs, Chinese HerbalMajor Depressive DisorderSerotoninAnimalsBrain-Derived Neurotrophic FactorC-Reactive ProteinHumansMaleRatsRats, Sprague-DawleyAnti-Anxiety AgentsAntidepressive AgentsBrain-Derived Neurotrophic FactorC-Reactive ProteinDrugs, Chinese HerbalSerotoninchamomilecrocusdepressiondiabetes mellitus

Identifiers

PMID39957158
PMCPMC11764942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.