ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025
Electroacupuncture alleviates zymosan-induced colorectal hypersensitivity.
Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Acupuncture inhibits astrocytic hyperactivationthe p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1 signaling pathway in cerebral ischemia-reperfusion injury.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Rikkunshito ameliorates colonic dysfunction and hormonal imbalance in an IBS mouse model with modulation of transient receptor potential channel activity.Frontiers in pharmacology · 2026Article
- The TRPV1 Channel Modulator Imidazo[1,2-a]Indole Derivative Exhibits Pronounced and Versatile Anti-Inflammatory Activity In Vivo.Biomedicines · 2025Article
- Gut sensory neurons as regulators of neuro-immune-microbial interactions: from molecular mechanisms to precision therapy for IBD/IBS.Journal of neuroinflammation · 2025Review
- Therapeutic effects of Poncirus fructus on colonic dysfunction and visceral pain in a zymosan-induced irritable bowel syndrome mouse model through interstitial cells of Cajal and ion channel modulation.Frontiers in pharmacology · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
objectivethis study to investigate the mechanism underlying the electroacupuncture (EA) alleviates colorectal hypersensitivity, a feature of irritable bowel syndrome (IBS).
methodsThe colorectal hypersensitivity model was established by treating mice with zymosan. Electrophysiological techniques, Western blotting and immunofluorescence staining were used to detect the changes of the sensitive state of the colorectum and the response in spinal ganglion and spinal cord after acupuncture intervention.
resultscolorectal distension studies revealed that repetitive applied electroacupuncture treatment on mice could significant alleviates colorectal intensity. Western blotting studies with nerve growth factor (NGF) in the colorectum, substance P (SP) in the spinal ganglion, protein kinase C gamma (PKCγ) in the spinal cord, and transient receptor potential vanilloid 1 (TRPV1) showed that electroacupuncture suppressed zymosan-induced expression of TRPV1, NGF and SP in multiple tissues. Immunofluorescence labeling results showed that EA attenuated the expression of NGF in the colorectum, SP in the spinal ganglion, PKCγ in the spinal cord, and TRPV1 in all three tissues in zymosan-treated mice. Moreover, the number of neurons double-positive for TRPV1/Isolectin B4 (IB4) and TRPV1/Neurofilament (NF) 200 was increased in the spinal ganglion.
conclusionthese results provide molecular-level evidence that EA alleviates zymosan-induced colorectal hypersensitivity by altering the expression of pain-associated proteins in the colorectum and spinal cord. EA has a potential to be therapeutic intervention option for IBS treatment.
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