Evidence map›Paper›PMID 39957153›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2025

Hewei Jiangni granule alleviates visceral hypersensitivity of non-erosive reflux diseasestromal interaction molecule 1/transient receptor potential vanilloid subfamily member 1 pathway.

Cheng Yuan, Zhang Xiaosi, L I Junxiang, Zhang Liming, Dai Yi, Xie Chune, Shi Lei, L I Xiaohong, Kou Fushun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng YuanSchool of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhang XiaosiGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
L I JunxiangGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Zhang LimingGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Dai YiGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Xie ChuneGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Shi LeiGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
L I XiaohongGastroenterology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.
Kou FushunCenter for IBD Research, Department of Gastroenterology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Funding

National Natural Science Foundation of China: Exploring the Molecular Mechanism of "Hewei Jiangni Fang" Intervention in Non-erosive Reflux Disease Esophageal Hypersensitivity from the Perspective of Mas-related Gene X2/Stromal Interaction Molecule 1/Cell Adhesion Molecule 1 Pathway Regulation of Mast Cell/Dorsal Root Ganglion Communication based on the "Xinkai-Kujiang" Method 82374401National Natural Science Foundation of China: Study on the Molecular Mechanism of the Regulation of Crypt Goblet Cell Pyroptosis and Exocytosis to Repair Ulcerative Colitis Mucus Barrier by the Method of Clearing and Opening the Xuanfu from the Perspective of "Xuanfu-Crypt" 82305143
6 · The paper itself

Abstract

objectiveTo explore if Hewei Jiangni granule (, HWJNG) could regulate esophageal hypersensitivity via stromal interaction molecule 1 (STIM1)/transient receptor potential vanilloid subfamily member 1 (TRPV1) pathway.

methodsQualitative analysis of HWJNG was analysis by high performance of liquid and gas chromatography.

resultsHWJNG significantly suppressed intercellular space widening, injury of mitochondrial, MCs degranulation, mechanical allodynia and heat neuropathic sensory and increased pH value of esophageal mucosa in NERD mice. HWJNG inhibited expression of visceral hypersensitivity-related gastrointestinal neurochemicals in esophageal mucosa and activated P815 cells, and expression of the STIM1, TRPV1 and related neurotransmitters in DRG and DRG cells. STIM1 siRNA and HWJNG both reduced P815 cells adhesion to DRGs cells and Ca

conclusionHWJNG suppressed intercellular space widening in NERD mice, stabilized MCs and restored neuronal hyperexcitability by regulating visceral hypersensitivity

Indexed as

Drugs, Chinese HerbalGastroesophageal RefluxStromal Interaction Molecule 1TRPV Cation ChannelsAnimalsHumansMaleMast CellsMiceMice, Inbred C57BLSignal TransductionDrugs, Chinese HerbalStromal Interaction Molecule 1TRPV1 protein, mouseTRPV Cation ChannelsHewei Jiangni granulenon-erosive reflux diseasestromal interaction molecule 1transient receptor potential channelsvisceral hypersensitivity

Identifiers

PMID39957153
PMCPMC11764939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.