Evidence map›Paper›PMID 39957151›Full record

ArticleFuture oncology (London, England)2025

REZILIENT3: randomized phase III study of first-line zipalertinib plus chemotherapy in patients with

John V Heymach, Helena A Yu, Benjamin Besse, Ying Cheng, Daniel Sw Tan, Li Wei, Volker Wacheck, Makoto Nishio

Abstract readClinical Trial Protocol
In one paragraph

Article in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Molecular epidemiology and outcomes ofTranslational lung cancer research · 2026
    Article
  3. Review
  4. Article
  5. Future oncology (London, England) · 2025
    Review
  6. Review
  7. Current paradigm of EGFRMed (New York, N.Y.) · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John V HeymachDepartment of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Helena A YuDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Benjamin BesseDepartment of Cancer Medicine, Institut Gustave Roussy, Paris-Saclay University, Villejuif, France.
Ying ChengDepartment of Thoracic Oncology, Jilin Cancer Hospital, Changchun, China.
Daniel Sw TanDivision of Medical Oncology, National Cancer Center Singapore, Duke-NUS Medical School, Singapore.
Li WeiClinical Development, Taiho Oncology, Inc, Princeton, NJ, USA.
Volker WacheckClinical Development, Taiho Oncology, Inc, Princeton, NJ, USA.
Makoto NishioDepartment of Thoracic Medical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

There remains a significant unmet need for effective and tolerable treatments for patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungLung NeoplasmsAcrylamidesAdultAgedClinical Trials, Phase III as TopicErbB ReceptorsExonsFemaleHumansMaleMiddle AgedMutagenesis, InsertionalMutationProtein Kinase InhibitorsAcrylamidesEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsEGFRepidermal growth factor receptorex20insexon 20 insertionsnon-small cell lung cancernonsquamous NSCLCNSCLCzipalertinib

Identifiers

PMID39957151
PMCPMC11845107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.