Evidence map›Paper›PMID 39957082›Full record

ArticlePhysiological reports2025

Metabolite pathway alterations identified by magnetic resonance metabolomics in a proximal tubular epithelial cell line treated with TGF-β1.

Tyrone L R Humphries, Soobin Lee, Aaron J Urquhart, David A Vesey, Aaron S Micallef, Clay Winterford, Andrew J Kassianos, Graham J Galloway, Ross S Francis, Glenda C Gobe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tyrone L R HumphriesKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.ORCID https://orcid.org/0000-0001-6735-6886
Soobin LeeKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.
Aaron J UrquhartKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.
David A VeseyKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.
Aaron S MicallefCentral Analytical Research Facility, Queensland University of Technology, Brisbane, Queensland, Australia.
Clay WinterfordQIMR-Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Andrew J KassianosConjoint Internal Medicine Laboratory, Chemical Pathology, Pathology Queensland, Brisbane, Queensland, Australia.
Graham J GallowayKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.
Ross S FrancisKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.
Glenda C GobeKidney Disease Research Collaborative, The University of Queensland and Translational Research Institute, Brisbane, Queensland, Australia.

Funding

RTP stipend from the Australian Government
6 · The paper itself

Abstract

Tubulointerstitial fibrosis is a characteristic hallmark of chronic kidney disease (CKD). Metabolic perturbations in cellular energy metabolism contribute to the pathogenesis of CKD, but the chemical contributors remain unclear. The aim of this investigation was to use two dimensional

Indexed as

Epithelial CellsKidney Tubules, ProximalTransforming Growth Factor beta1Cell LineFibrosisHumansMagnetic Resonance SpectroscopyMetabolomeMetabolomicsRenal Insufficiency, ChronicTransforming Growth Factor beta12D‐COSYmetabolomicsmetabonomicsNMR, nuclear magnetic resonanceproximaltubular epithelial cellTGF‐β1two‐dimensional correlated spectroscopy

Identifiers

PMID39957082
PMCPMC11830627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.