Evidence map›Paper›PMID 39956879›Full record

ArticleClinical oral investigations2025

Ion release, cytocompatibility and microbial inhibition of a novel varnish containing fluoride-doped bioactive glass ceramics: an in vitro study.

Panmella Pereira Maciel, Eudes Leonnan Gomes de Medeiros, Lucas Ricardo Fernandes Figueiredo, Rebeca Tibau Aguiar Dias, Eduarda Gomes Onofre de Araújo, Roberta Ferreti Bonan Dantas Batista, Sara Brito Silva Costa Cruz, Ricardo Dias de Castro, Joelma Rodrigues de Souza, Eliton Souto de Medeiros and 3 more

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Panmella Pereira MacielLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil. panmellamaciel@hotmail.com.
Eudes Leonnan Gomes de MedeirosLaboratory of Materials Technology (LTM), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande, Paraiba, Brazil.
Lucas Ricardo Fernandes FigueiredoMaterials and Biosystems Laboratory (LAMAB), Department of Materials Engineering, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Rebeca Tibau Aguiar DiasLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Eduarda Gomes Onofre de AraújoLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Roberta Ferreti Bonan Dantas BatistaLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Sara Brito Silva Costa CruzLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Ricardo Dias de CastroLaboratory of Experimental Pharmacology and Cell Culture (LAFECC), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Joelma Rodrigues de SouzaLaboratory of Immunology and Cell Culture (LABIMH), Department of Physiology and Pathology, Federal University of Paraíba, João Pessoa, PB, Brazil.
Eliton Souto de MedeirosMaterials and Biosystems Laboratory (LAMAB), Department of Materials Engineering, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Romualdo Rodrigues MenezesLaboratory of Materials Technology (LTM), Department of Materials Engineering, Federal University of Campina Grande, Campina Grande, Paraiba, Brazil.
André Ulisses Dantas BatistaLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.
Paulo Rogério Ferreti BonanLaboratory of Biomaterials (LABIO), Dentistry Graduation Program, Federal University of Paraíba, João Pessoa, Paraiba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe study aimed to develop and evaluate in vitro a varnish containing fluoride-doped glass ceramics capable of inhibiting oral microorganisms, releasing hydroxyapatite-forming ions, and ensuring biocompatibility. MATERIALS AND

methodsFor the production of the experimental varnish (VE), composed of hydrogenated rosin, 10% and 20% by weight of glass ceramics with composition S53P4 (CF0) and doped with F- ions (CF5 and CF10) were incorporated. The EVs were characterized by Rheology, Scanning Electron Microscopy (SEM), FTIR, ion release (fluoride and calcium ions), cytotoxicity on VERO cells, and antimicrobial effect on S. mutans, S. aureus and C. albicans and anti-biofilm effect on S. mutans. The data were analyzed by One-Way ANOVA and Kruskal-Wallis test (P = 0.05).

resultsHomogeneous varnishes with good viscosity were obtained. Varnishes with 20% CF demonstrated biocompatibility and minimum inhibitory concentration (MIC) at concentrations lower than 10 mg/mL and 3.12 mg/mL, respectively, except for C. albicans. An anti-biofilm effect on S. mutans was observed for the varnishes with 20% CF. All varnishes with CF released more F- than the commercial varnish, with V20CF10 standing out, which released 4 times more F- ions in a quarter of the time.

conclusionsThe V20CF10 varnish is a promising material for dental use in the treatment of early caries lesions, due to its biocompatibility, antimicrobial properties, and release of hydroxyapatite-forming ions. CLINICAL RELEVANCE: The use of a new varnish that combines antimicrobial properties with hydroxyapatite-forming ion release may prevent or halt the progression of dental caries lesions, offering greater efficacy than currently available varnishes.

Indexed as

CeramicsFluoridesFluorides, TopicalAnimalsAnti-Infective AgentsBiocompatible MaterialsBiofilmsCandida albicansChlorocebus aethiopsGlassIn Vitro TechniquesMaterials TestingMicrobial Sensitivity TestsMicroscopy, Electron, ScanningRheologySpectroscopy, Fourier Transform InfraredAnti-Infective AgentsBiocompatible MaterialsFluoridesFluorides, TopicalGlass ceramicsAntibiofilmFluorideGlass ceramicsReleaseVarnish

Identifiers

PMID39956879

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.