Evidence map›Paper›PMID 39956872›Full record

ArticleScientific reports2025

Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis.

Min Zhong, Hongjin An, Huatian Gan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Exploring the Potential Roles ofInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Min Zhong *Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Hongjin An *Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu, China.
Huatian GanDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China. ganhuatian123@163.com.

Funding

1.3.5 Project for Disiplines of Excellence, West China Hospital, Sichuan University ZYGD23013National Natural Science Foundation of China 82070560
6 · The paper itself

Abstract

To investigate the causal relationship between inflammatory bowel disease (IBD) and uveitis, we conducted a two-sample bidirectional Mendelian randomization (MR) analysis utilizing summary data from genome-wide association studies (GWAS). The primary statistical analysis was performed using the inverse-variance weighted (IVW) method. False discovery rate (FDR) correction was used to control for false positives in multiple testing. In addition, sensitivity analyses were carried out using the MR Egger intercept test and Cochran's Q test. The MR analysis revealed that genetically determined IBD (OR = 1.141, 95% CI 1.080-1.205, P = 2.21 × 10

Indexed as

Inflammatory Bowel DiseasesMendelian Randomization AnalysisUveitisColitis, UlcerativeCrohn DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideCausal relationshipCrohn’s diseaseInflammatory bowel diseaseMendelian randomizationUlcerative colitisUveitis

Identifiers

PMID39956872
PMCPMC11830775

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.