Evidence map›Paper›PMID 39956855›Full record

ArticleLung2025

PDE4B Modulates Phosphorylation of p65 (Ser468) via cAMP/PKA in Acute Lung Injury.

Rana Dhar, Yajun Li, Zhengqiang Hu, Shunde Song, Zhewen Zhang, Jie Ji, Xuefeng Wang, Xuyang Zheng, Zigang Li, Chunguang Yan and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Lung, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rana Dhar *Department of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Yajun Li *Department of Pharmacy, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, 410008, China.
Zhengqiang Hu *Department of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Shunde Song *Department of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Zhewen ZhangDepartment of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Jie JiDepartment of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China.
Xuefeng WangDepartment of Pharmacy, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang, China.
Xuyang ZhengDepartment of Pediatrics, The Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China.
Zigang LiDepartment of Anesthesiology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, China.
Chunguang YanDepartment of Pathogenic Biology and Immunology, Medical School of Southeast University, Nanjing, 210009, China. ycgagcy@163.com.
Huifang TangDepartment of Pharmacology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310058, Zhejiang, China. tanghuifang@zju.edu.cn.

Funding

Huifang Tang 81570056
6 · The paper itself

Abstract

aimThe important role of phosphodiesterase 4B (PDE4B) inhibition on lipopolysaccharide (LPS)-induced ALI has been reported. However, the corresponding mechanisms remain unclear. In the present study, the relationship between PDE4B and phosphorylation of p65 (Ser468) in LPS-induced injury by in vivo and in vitro models was investigated. METHODS AND

resultspde4b

conclusionsPDE4B plays a critical role in orchestrating LPS-induced acute lung inflammation by cAMP/PKA axis-mediated phosphorylation of p65.

Indexed as

Acute Lung InjuryCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 4LungTranscription Factor RelAAnimalsDisease Models, AnimalLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationSignal TransductionCyclic AMPCyclic AMP-Dependent Protein KinasesCyclic Nucleotide Phosphodiesterases, Type 4LipopolysaccharidesPDE4B protein, mouseRela protein, mouseTranscription Factor RelAAcute lung injuryMacrophagep65PDE4BPKA

Identifiers

PMID39956855

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.