Evidence map›Paper›PMID 39956825›Full record

ArticleNature communications2025

Tissue factor-dependent colitogenic CD4

Gemma Leon, Paula A Klavina, Aisling M Rehill, Sarah E J Cooper, Anna Dominik, Shrikanth Chomanahalli Basavarajappa, James S O'Donnell, Seamus Hussey, Patrick T Walsh, Roger J S Preston

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gemma LeonIrish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID http://orcid.org/0000-0002-3903-9389
Paula A KlavinaIrish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID http://orcid.org/0000-0001-8294-343X
Aisling M RehillIrish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Sarah E J CooperNational Centre for Paediatric Gastroenterology, CHI-Crumlin, Dublin, Ireland.ORCID http://orcid.org/0009-0009-4845-0434
Anna DominikNational Centre for Paediatric Gastroenterology, CHI-Crumlin, Dublin, Ireland.
Shrikanth Chomanahalli BasavarajappaDepartment of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.
James S O'DonnellIrish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Seamus HusseyNational Centre for Paediatric Gastroenterology, CHI-Crumlin, Dublin, Ireland.
Patrick T WalshDepartment of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-0130-8766
Roger J S PrestonIrish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, RCSI University of Medicine and Health Sciences, Dublin, Ireland. rogerpreston@rcsi.ie.ORCID http://orcid.org/0000-0003-0108-4077

Funding

Health Research Board (HRB) ILPPOR-2022-060Science Foundation Ireland (SFI) 21/FFP-A/8859Science Foundation Ireland (SFI) 21/FFP-P/10135
6 · The paper itself

Abstract

Patients with inflammatory bowel disease (IBD) have an increased risk of venous thromboembolism (VTE), but the underlying mechanistic basis remains poorly defined. Here, we find that colitogenic CD4

Indexed as

CD4-Positive T-LymphocytesColitisInflammatory Bowel DiseasesProtein CThromboplastinAnimalsBlood CoagulationColonFemaleHumansMaleMiceMice, Inbred C57BLSignal TransductionThrombinVenous ThromboembolismProtein CThrombinThromboplastin

Identifiers

PMID39956825
PMCPMC11830781

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.