Evidence map›Paper›PMID 39956803›Full record

ArticleNature communications2025

Digital aberration correction for enhanced thick tissue imaging exploiting aberration matrix and tilt-tilt correlation from the optical memory effect.

ChulMin Oh, Herve Hugonnet, Moosung Lee, YongKeun Park

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

ChulMin OhDepartment of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0009-0004-9518-6377
Herve HugonnetDepartment of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
Moosung LeeDepartment of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.
YongKeun ParkDepartment of Physics, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. yk.park@kaist.ac.kr.ORCID http://orcid.org/0000-0003-0528-6661

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Optical aberrations significantly impair microscopic image quality across various domains, including cell biology and histopathology diagnostics. Traditional adaptive optics techniques, such as wavefront shaping and guide star utilization, face challenges, especially in imaging biological tissues. Here, we introduce a computational adaptive optics approach tailored for optically thick samples. Utilizing the tilt-tilt correlation from the optical memory effect, our method detects phase differences in aberrations caused by small tilts in the incident waves. Experimental validation demonstrates our technique's capacity to enhance imaging of thick human tissues under substantial aberration conditions using a transmission-mode holotomography setup. Remarkably, our approach works robustly against sample movement, which is essential for enhanced imaging accuracy in critical biomedical applications.

Indexed as

Image Processing, Computer-AssistedMicroscopyHolographyHumansOptics and Photonics

Identifiers

PMID39956803
PMCPMC11830826

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.