Evidence map›Paper›PMID 39956640›Full record

ArticleObesity (Silver Spring, Md.)2025

Loss of VSTM2A promotes adipocyte hypertrophy and disrupts metabolic homeostasis.

Manal Al Dow, Blandine Secco, Mathilde Mouchiroud, Marianne Rochette, Gustavo R Gilio, Mickael Massicard, Marilou Hardy, Yves Gélinas, William T Festuccia, Mathieu C Morissette and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Manal Al DowCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Blandine SeccoCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Mathilde MouchiroudCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Marianne RochetteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Gustavo R GilioInstitute of Biomedical Sciences, Department of Physiology and Biophysics, University of São Paulo, São Paulo, Brazil.
Mickael MassicardCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Marilou HardyCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Yves GélinasCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
William T FestucciaInstitute of Biomedical Sciences, Department of Physiology and Biophysics, University of São Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-4769-0806
Mathieu C MorissetteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.
Venkata S K ManemCentre de recherche sur le cancer de l'Université Laval, Université Laval, Quebec, Québec City, Canada.
Mathieu LaplanteCentre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Faculté de Médecine, Université Laval, Quebec, Québec City, Canada.ORCID https://orcid.org/0000-0002-1752-6741

Funding

Canadian Institutes of Health Research (CIHR) 153318Canadian Institutes of Health Research (CIHR) 166168FRQS - Doctoral Research Scholarship 302513FRQS - Junior 1 296296La Fondation de l'Institut universitaire de cardiologie et de pneumologie de Quebéc, Université Laval (IUCPQ-UL)Les Fonds de Recherche du Québec-Santé Santé (FRQS) - Chercheur Senior and Chercheur Mérite 312374Les Fonds de Recherche du Québec-Santé Santé (FRQS) - Chercheur Senior and Chercheur Mérite 350476
6 · The paper itself

Abstract

objectiveAdipose tissue expands through hyperplasia and hypertrophy to store excess lipids, a process that is essential for the maintenance of metabolic homeostasis. The mechanisms regulating adipocyte recruitment from progenitors remain unclear. We have previously identified V-set and transmembrane domain-containing protein 2A (VSTM2A) as a factor promoting fat cell development in vitro. Whether VSTM2A impacts adipose tissue and systemic metabolism in vivo is still unknown.

methodsWe generated VSTM2A knockout mice (Vstm2a

resultsVstm2a

conclusionsVSTM2A is dispensable for adipose tissue formation, but its loss causes adipocyte hypertrophy and impairs glucose and lipid homeostasis. Our study also underscores a critical role of the lysosome in initiating adipogenesis.

Indexed as

AdipocytesHomeostasisMembrane ProteinsAdipogenesisAdipose TissueAdiposityAnimalsDiet, High-FatHypertrophyLipid MetabolismMaleMiceMice, Inbred C57BLMice, KnockoutObesityMembrane Proteins

Identifiers

PMID39956640
PMCPMC11897849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.