Evidence map›Paper›PMID 39956623›Full record

Observational studyThe Journal of international medical research2025

Relationship between plasma polymyxin B concentrations and acute kidney injury in critically ill elderly patients: Findings from a prospective study.

Changyun Zhao, Wenchao Mao, Feifei Ye, Kailun Cai, Shijin Gong, Cong Ye, Yihua Yu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Changyun ZhaoDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Wenchao MaoDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Feifei YeDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Kailun CaiDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Shijin GongDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Cong YeDepartment of Critical Care Medicine, Zhejiang Hospital, Zhejiang, China.
Yihua YuDepartment of Integrated Ward, Zhejiang Hospital, Zhejiang, China.ORCID 0000-0002-9828-0295

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to determine the relationship between the plasma polymyxin B concentration and renal function in elderly patients.

methodsThis prospective, case-control, observational study included elderly patients who received polymyxin B therapy and were divided into an acute kidney injury (AKI) group and a non-AKI group based on their renal function. We monitored the pharmacokinetics and pharmacodynamics of polymyxin B, including the minimum plasma concentration (C

resultsThe loading doses, C

conclusionMonitoring plasma polymyxin B concentrations is essential in elderly patients. Keeping the C

Indexed as

Acute Kidney InjuryAnti-Bacterial AgentsPolymyxin BAgedAged, 80 and overArea Under CurveCase-Control StudiesCritical IllnessFemaleHumansMaleProspective StudiesROC CurveAnti-Bacterial AgentsPolymyxin Bacute kidney injuryelderly patientspharmacodynamicspharmacokineticsPolymyxin Btherapeutic drug monitoring

Identifiers

PMID39956623
PMCPMC11831629

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.