Evidence map›Paper›PMID 39956334›Full record

ArticleGastroenterology2025

The MODY-Causing Mutation of the Human Carboxyl Ester Lipase Gene (CEL) Triggers Chronic Pancreatitis But Not Diabetes in Mice.

Anny Gravdal, Steven J Wilhelm, CEL-MODY Mouse Project, Mark E Lowe, Anders Molven, Xunjun K Xiao, Karianne Fjeld

Abstract read
In one paragraph

Article in Gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anny GravdalThe Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Steven J WilhelmDepartment of Pediatrics, Washington University School of Medicine, St Louis, Missouri.
CEL-MODY Mouse Project
Mark E LoweDepartment of Pediatrics, Washington University School of Medicine, St Louis, Missouri.
Anders MolvenThe Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Section for Cancer Genomics, Laboratory Clinic, Bergen, Norway; Department of Pathology, Haukeland University Hospital, Bergen, Norway.
Xunjun K XiaoDepartment of Pediatrics, Washington University School of Medicine, St Louis, Missouri.
Karianne FjeldThe Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway. Electronic address: karianne.fjeld@uib.no.

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8M
WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
Molecular Mechanisms of Dietary Fat Digestion by Pancreatic LipasesR01DK080820 · NIDDK · WASHINGTON UNIVERSITY · PI LOWE, MARK E. · 2009 to 2017
$2.7M
Pathophysiology of Chronic Pancreatitis Associated with Misfolded PNLIP Risk VariantsR01DK128188 · NIDDK · WASHINGTON UNIVERSITY · PI XIAO, XUNJUN · 2022 to 2025
$1.8M
Does Proteotoxicity Contribute to Chronic Pancreatitis in Murine Models of Human Carboxyl Ester Lipase (CEL) Genetic Risk Variants?R01DK124415 · NIDDK · WASHINGTON UNIVERSITY · PI LOWE, MARK E. · 2020 to 2023
$1.8M
NIDDK NIH HHS P30 DK020579NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK080820NIDDK NIH HHS R01 DK124415NIDDK NIH HHS R01 DK128188
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39956334
PMCPMC12185230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.