ReviewBiological psychiatry2025
Mapping Structural Neuroimaging Trajectories in Bipolar Disorder: Neurobiological and Clinical Implications.
Review in Biological psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Structural Brain Network Alterations in Relation to Treatment and Illness Severity in Bipolar Disorder.Biological psychiatry · 2026Article
- Machine Learning-Based Identification of Functional Dysregulation Characteristics in Core Brain Networks of Adolescents with Bipolar Disorder Using Task-fMRI.Diagnostics (Basel, Switzerland) · 2026Article
- Bivariate GSA-MiXeR: A Novel Tool for Functional Genomic Analyses Implicates Diverse Neural Cell Types for Psychiatric and Neurodegenerative Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Predicting Mental and Neurological Illnesses Based on Cerebellar Normative Features.Biological psychiatry global open science · 2025Article
- Bipolar disorder integrative staging: incorporating biomarkers into progression across stages (BOARDING-PASS) - rationale and design.Frontiers in psychiatry · 2025Article
- Bioinformed idiographic symptom networks to identify neurobiological predictors of affective-state transitions in bipolar disorder.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Neuroimaging is a powerful noninvasive method for studying brain alterations in bipolar disorder (BD). To date, most neuroimaging studies of BD have included smaller cross-sectional samples reporting case versus control comparisons, revealing small to moderate effect sizes. In this narrative review, we discuss the current state of structural neuroimaging studies using magnetic resonance imaging, which inform our understanding of altered brain trajectories in BD across the lifespan. Alternative methodologies such as those that model patient deviations from age-specific norms are discussed, which may help derive new markers of BD pathophysiology. We discuss evidence from neuroimaging genetics and transcriptomics studies, which attempt to bridge the gap between macroscale brain variations and underlying microscale neurodevelopmental mechanisms. We conclude with a look toward the future and how ambitious investments in longitudinal, deeply phenotyped, population-based cohorts can improve modeling of complex clinical factors and provide more clinically actionable brain markers for BD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.