Evidence map›Paper›PMID 39955688›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2025

Skeletal health status among patients with chronic hypoparathyroidism: results from the Canadian National Hypoparathyroidism Registry (CNHR).

Aliya A Khan, Hajar AbuAlrob, Dalal S Ali, Zayd Al Kassem, Abdulrahman Almoulia, Habiba Afifi, Manoela Braga, Alice Cheng, Jouma Malhem, Adam Millar and 13 more

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Aliya A KhanDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada. draliyakhan@gmail.com.ORCID http://orcid.org/0000-0003-3733-8956
Hajar AbuAlrobDepartment of Health Research Methodology, McMaster University, Hamilton, ON, Canada.
Dalal S AliDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada.
Zayd Al KassemBone Research and Education Centre, Oakville, Canada.
Abdulrahman AlmouliaBone Research and Education Centre, Oakville, Canada.
Habiba AfifiBone Research and Education Centre, Oakville, Canada.
Manoela BragaDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada.
Alice ChengDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Jouma MalhemBone Research and Education Centre, Oakville, Canada.
Adam MillarThe Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON, Canada.
Emmett MorganteBone Research and Education Centre, Oakville, Canada.
Parwana MuhammadBone Research and Education Centre, Oakville, Canada.
Terri L PaulWestern University, London, ON, Canada.
Ally PrebtaniDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada.
Zubin PunthakeeDivision of Endocrinology and Metabolism, McMaster University, Hamilton, ON, Canada.
Tayyab KhanWestern University, London, ON, Canada.
Sarah KhanBone Research and Education Centre, Oakville, Canada.
Muhammad ShrayyefUniversity of Toronto, Toronto, ON, Canada.
Stan Van UumWestern University, London, ON, Canada.
James Edward Massey YoungDivision of Otolaryngology-Head and Neck SurgeryDepartment of Surgery, McMaster University, Hamilton, ON, Canada.
Maria Luisa BrandiF.I.R.M.O. Onlus Italian Foundation for the Research On Bone Diseases, Florence, Italy.
Michel OvizeAmolyt Pharma, Ecully, France.
Blandine WeissAmolyt Pharma, Ecully, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the CNHR study, 35% of postmenopausal women had osteoporosis by BMD or fragility fracture, and 4% had both. Three men ≥ 50 had osteoporosis by BMD or fragility fracture (33.3%; n = 3/9). This suggests that close follow-up of skeletal health is necessary in postmenopausal women, and men ≥ 50 with chronic HypoPT. PURPOSE: Chronic hypoparathyroidism (HypoPT) has been associated with decreased bone turnover and abnormalities in bone mineral density (BMD), microarchitecture, and strength. Current guidelines do not recommend systematic evaluation of skeletal health in patients with chronic HypoPT. Our study assessed skeletal health in pre- and postmenopausal women with chronic HypoPT and adult men.

methodsThis prospective study enrolled adults with chronic HypoPT from the Canadian National Hypoparathyroidism Registry. Clinical characteristics, bone fractures, biochemistry, and serum bone biomarkers were assessed at baseline. Skeletal health evaluation included assessments of fragility fractures, BMD at lumbar spine (LS), femoral neck (FN), total hip (TH), 1/3 radial sites, trabecular bone score (TBS), and bone biomarkers.

resultsWe present the baseline data of the patients enrolled in the registry. We analyzed a total of 101 patients: 18 men, 35 premenopausal, and 48 postmenopausal women. The mean (SD) age at the onset of HypoPT was 40.7 (16.8) years, and the average disease duration was 11.2 (8.6) years. The most common etiology was postsurgical (74.3% vs. 25.7% non-surgical). Most patients received calcium supplements (89%) and active vitamin D (80%) at baseline. No fragility fractures or low BMD were reported in premenopausal women. However, BMD at LS, FN, TH, and TBS were significantly lower in postmenopausal compared to premenopausal women.

conclusionsOverall, 35% of postmenopausal women had osteoporosis by BMD or prior fragility fracture, and 4% had both. Three men ≥ 50 years had osteoporosis by BMD or fragility fracture (33.3%; n = 3/9). This study suggests that close follow-up of skeletal health is necessary in postmenopausal women with chronic HypoPT and men ≥ 50 years.

Indexed as

HypoparathyroidismOsteoporosisAbsorptiometry, PhotonAdultAgedBiomarkersBone DensityCanadaChronic DiseaseFemaleFemur NeckHip JointHumansLumbar VertebraeMaleMiddle AgedBiomarkersFragility fractureHypoparathyroidismOsteoporosisPostmenopausal womenSkeletal health

Identifiers

PMID39955688
PMCPMC12064612

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.