ArticleMolecular therapy : the journal of the American Society of Gene Therapy2025
Immunological responses and clinical outcomes in dogs with osteosarcoma receiving standard therapy and a Listeria vaccine expressing HER2.
Abstract readClinical Trial, VeterinaryMulticenter Study
In one paragraph
Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Integrated Multiomic Profiling Enhances Risk Stratification and Prognostication in Canine Osteosarcoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Combined radiation andMolecular therapy. Oncology · 2026Article
- Navigating the immunosuppressive abyss: current hurdles and innovative breakthroughs in neoadjuvant immunotherapy for osteosarcoma.Frontiers in immunology · 2026Review
- High-resolution single-cell RNA sequencing using canFam4 reveals novel immune subsets and checkpoint programs in healthy dogs.Frontiers in immunology · 2025Article
- Comparative oncology in action: vignettes on immunotherapy development.Veterinary oncology (London, England) · 2025Review
- Osteosarcoma of the appendicular skeleton in dogs: consensus and guidelines.Frontiers in veterinary science · 2025Review
- Preclinical safety assessment and immunological evaluation of xenogeneic mammary cells of porcine origin, utilized as an intralesional immunotherapeutic agent.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors.
Nicola J MasonDepartment of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA. Electronic address: nmason@vet.upenn.edu.
Laura SelmicDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Audrey RupleDepartment of Population Health Sciences, Virginia Tech, Blacksburg, VA 24061, USA.
Cheryl A LondonDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.
Lisa BarberDepartment of Clinical Sciences, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.
Kristen WeishaarFlint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80525, USA.
James A PerryCASTR Alliance, 22524 SE 64(th) Place, Suite 2258, Issaquah, WA 98027, USA.
Jennifer MahoneyDepartment of Clinical Sciences & Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Brian FlesnerDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Jeffrey N BryanDepartment of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Jennifer L WillcoxDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
Jenna H BurtonDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, USA.
David M VailDepartment of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI 53706, USA.
William C KisseberthDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, OH 43210, USA.
Cheryl E BalkmanDepartment of Clinical Science, Cornell University College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Angela L McCleary-WheelerDepartment of Clinical Science, Cornell University College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Katie M CurranDepartment of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 43210, USA.
Haley LeeperDepartment of Clinical Sciences, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR 43210, USA.
John Paul WoodsDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON NWG 2W1, Canada.
Anthony J MutsaersDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON NWG 2W1, Canada.
Mary Lynn HigginbothamDepartment of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66502, USA.
Raelene M WoudaOncology Service, Veterinary Specialist Services, Underwood, QLD 4119, Australia.
Heather Wilson-RoblesEthos Discovery, 10435 Sorrento Valley Road, San Diego, CA 92121, USA.
Nicholas DervisisCollege of Veterinary Medicine and Purdue Institute for Cancer Research, Purdue University, West Lafayette, IN 47907, USA.
Corey SabaDepartment of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Valerie S MacDonald-DickinsonDepartment of Small Animal Clinical Sciences, University of Saskatchewan, Saskatoon, SK SN7 5B4, Canada.
Paul R HessDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA.
Aswini CherukuriComparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Antonia RotoloDepartment of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Jessica A BeckComparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Sushant PatkarComparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Artificial Intelligence Resource, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Christina MazckoComparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Amy K LeBlancComparative Oncology Program, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A clinical trial in dogs with spontaneous osteosarcoma was performed to assess a recombinant Listeria expressing a chimeric human HER2 (ADXS31-164
Indexed as
Bone NeoplasmsCancer VaccinesDog DiseasesErb-b2 Receptor Tyrosine KinasesListeriaOsteosarcomaAnimalsCytokinesDogsFemaleHumansMaleTreatment OutcomeCancer VaccinesCytokinesErb-b2 Receptor Tyrosine Kinasescorrelative biomarkersdogHER2/neuimmunotherapylarge animal modelListeria vectorosteosarcomapre-clinical studyvaccine
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.