Evidence map›Paper›PMID 39955550›Full record

SynthesisBMC women's health2025

Associations of the gut, cervical, and vaginal microbiota with cervical cancer: a systematic review and meta-analysis.

Qin Wen, Shubin Wang, Yalan Min, Xinyi Liu, Jian Fang, Jinyi Lang, Meihua Chen

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qin WenSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Shubin WangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Yalan MinSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Xinyi LiuSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Jian FangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, 610041, China.
Jinyi LangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, 610054, China. langjy610@163.com.
Meihua ChenDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan, 610041, China. chenmeihua@scszlyy.org.cn.

Funding

Chengdu Science and Technology Bureau 2024-YF05-02230-SNHealth Commission of Sichuan Province 2024-803Health Commission of Sichuan Province Medical Science and Technology Program 24QNMP038
6 · The paper itself

Abstract

backgroundAn increasing number of studies indicate that the gut, cervical, and vaginal microbiota may play crucial roles in the development of cervical cancer (CC). However, the interactions between the microbiota and the host are yet unknown. To address this gap, a systematic review and meta-analysis were conducted to assess the microbiota alterations in a variety of body locations, including the gut and genital tract.

methodsElectronic searches of PubMed, Embase, Web of Science, and the Cochrane Library were conducted to retrieve eligible papers published from January 1, 2014, to January 1, 2024 (PROSPERO: CRD42024554433). This study was restricted to English-language studies reporting on alpha diversity, beta diversity, and relative abundance, as well as on patients with CC whose microbiota had been analyzed via next-generation sequencing technologies. To assess the risk of bias (RoB), we utilized the Newcastle‒Ottawa Quality Assessment Scale (NOS) and the ROBINS-I tool. For the meta-analysis, we employed Review Manager 5.4.

resultsThirty-six eligible studies were included in this review. The Chao1 index (SMD = 0.96, [95% CI: 0.71, 1.21], I

conclusionThis systematic review elucidates the microbiota alterations associated with the prevalence of CC and its response to anti-tumor therapies, aiming to provide insights for future research directions and precision medicine strategies to enhance women's quality of life. PROSPERO REGISTRATION: CRD42024554433.

Indexed as

Cervix UteriGastrointestinal MicrobiomeMicrobiotaUterine Cervical NeoplasmsVaginaFemaleHumans16S rRNA sequencingCervical cancerCervical microbiotaDysbiosisGut microbiomeMeta-analysisVaginal microbiota

Identifiers

PMID39955550
PMCPMC11829412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.