ArticleBMC oral health2025
Association of leukocyte telomere length with periodontal attachment loss based on a cross-sectional study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The association of periodontitis with telomere length: a meta-analysis.BMC medical genomics · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukocyte telomere length (LTL) has been implicated in various health outcomes, but its association with attachment loss in periodontal health remains underexplored.
methodsA total of 2521 US adults (Age: 61-85; Men: 50.5%) from the National Health and Nutrition Examination Survey (1999-2002) were included in this cross-sectional study. Baseline demographics were obtained from the questionaries, and LTL was determined using a polymerase chain reaction, and periodontal attachment loss was defined according to a professional physical examination. Multivariable regression analyses were conducted to assess the association between LTL, treated as a categorical and continuous variable, and periodontal attachment loss. The sensitivity analysis was verified by subgroup analyse, where interaction terms were used to examine the heterogeneity in associations across different subgroups.
resultsCompared to the lowest quartile, the highest LTL quartile exhibited a significant positive association with periodontal attachment loss in the fully-adjusted model (β: 1.54 to 1.71, P < 0.05). When LTL was treated as a continuous variable, a positive association persisted in the fully-adjusted model (β: 2.22 to 3.24, P < 0.05). Subgroup analyses revealed a consistent positive association between LTL and periodontal attachment loss.
conclusionsThis study provides evidence of a positive association between leukocyte telomere length and attachment loss in periodontal health. Our results suggested that LTL may serve as a potential biomarker for periodontal health, emphasizing the importance of considering telomere length in understanding and managing periodontal conditions.
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