ArticleBMC medical imaging2025
Correlation between hemodynamics assessed by FAI combined with CT-FFR and plaque characteristics in coronary artery stenosis.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Serum calcium levels are independently associated with severe coronary artery stenosis combined with severe cerebral artery stenosis.BMC neurology · 2026Article
- Coronary CT Angiography-Based Prediction Model for Hemodynamically Significant Coronary Stenosis Integrating Morphological and Plaque Characteristics.Cardiovascular engineering and technology · 2026Article
- Subtraction fractional flow reserve with computed tomography and pericoronary fat attenuation index enhances the identification of revascularization needs in patients.BMC medical imaging · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile both CT-FFR and FAI are found to be associated with the development of CAD, their relationship with hemodynamics and plaque characteristics remains unclear. The present study aims to investigate the relationship between hemodynamics assessed by FAI combined with CT-FFR and plaque characteristics in functionally significant coronary artery stenosis.
methodsThis retrospective study included 130 patients with suspected coronary heart disease, who were admitted to the Department of Cardiology of our hospital and underwent coronary computed tomography angiography (CCTA) from January 2022 to December 2023. Clinical baseline data and relevant auxiliary examination results were collected, and CCTA, FAI, and CT-FFR data were analyzed to investigate the relationship between these imaging parameters and both the hemodynamics and plaque characteristics of coronary artery lesions.
resultsFrom 130 patients, a total of 207 diseased vessels were analyzed and classified based on CAD-RADS grading: 128 vessels exhibited stenosis of less than 50%, and 79 exhibited stenosis exceeding 50%. Patients with more than one lesion of > 50% stenosis were classified into the myocardial ischemia group (44 cases), and the rest were categorized as the non-myocardial ischemia group (86 cases). Compared to the non-myocardial ischemia group, patients in the myocardial ischemia group were significantly older (p < 0.001). No significant difference was found between the two groups in sex, cardiovascular risk factors, or the indicator of stenotic vessel distribution. The minimum CT-FFR in vessels with < 50% stenosis was higher than in vessels with > 50% stenosis, ΔCT-FFR was lower in vessels with < 50% stenosis than in vessels with > 50% stenosis, and the median CT-FFR was significantly lower in vessels with > 50% stenosis than in vessels with < 50% stenosis (p < 0.001). Additionally, FAI-LAD, FAI-LCX, FAI-RCA, and FAI-Mean were found to be significantly higher in vessels with > 50% stenosis compared to vessels with < 50% stenosis (p < 0.05). A negative correlation was observed between the minimum CT-FFR among three main coronary arteries (LAD, LCX, RCA) and CAD-RADS classification, while both ΔCT-FFR and FAI were positively correlated with CAD-RADS classification (p < 0.05). Non-calcified plaques were more prevalent in the vessels with > 50% stenosis, primarily located in the LAD, while calcified plaques were predominantly observed in vessels with < 50% stenosis (p < 0.001). In addition, in vessels with > 50% stenosis, plaques were longer, the degree of luminal stenosis was greater, and both the total volume and burden of plaques were significantly greater than in vessels with < 50% stenosis (p < 0.001). Lastly, the FAI
conclusionFAI is associated with coronary artery stenosis and myocardial ischemia, and may serve as a novel indicator for identifying myocardial ischemia. Both FAI and CT-FFR demonstrated strong predictive abilities in significant coronary stenosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.