Evidence map›Paper›PMID 39955481›Full record

ArticleBMC genomic data2025

Complete genome assemblies and antibiograms of 22 Staphylococcus capitis isolates.

Yu Wan, Rachel Pike, Alessandra Harley, Zaynab Mumin, Isabelle Potterill, Danièle Meunier, Mark Ganner, Maria Getino, Juliana Coelho, Elita Jauneikaite and 6 more

Abstract read
In one paragraph

Article in BMC genomic data, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yu WanHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom. yu.wan@liverpool.ac.uk.
Rachel PikePublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Alessandra HarleyPublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Zaynab MuminPublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Isabelle PotterillPublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Danièle MeunierHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.
Mark GannerPublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Maria GetinoNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Juliana CoelhoHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.
Elita JauneikaiteNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Kartyk MoganeradjPublic Health Microbiology Reference Services, Specialised Microbiology & Laboratories, UK Health Security Agency, London, United Kingdom.
Colin S BrownHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.
Alison H HolmesNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Alicia DemirjianHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.
Katie L HopkinsHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.
Bruno PichonHCAI, Fungal, AMR, AMU and Sepsis Division, UK Health Security Agency, London, United Kingdom.

Funding

National Institute for Health and Care Research NIHR200876Price David Evans endowment UGG10057Wellcome TrustWellcome Trust PSN109
6 · The paper itself

Abstract

objectiveStaphylococcus capitis is part of the human microbiome and an opportunistic pathogen known to cause catheter-associated bacteraemia, prosthetic joint infections, skin and wound infections, among others. Detection of S. capitis in normally sterile body sites saw an increase over the last decade in England, where a multidrug-resistant clone, NRCS-A, was widely identified in blood samples from infants in neonatal intensive care units. To address a lack of complete genomes and antibiograms of S. capitis in public databases, we performed long- and short-read whole-genome sequencing, hybrid genome assembly, and antimicrobial susceptibility testing of 22 diverse isolates. DATA DESCRIPTION: We present complete genome assemblies of two S. capitis type strains (subspecies capitis: DSM 20326; subspecies urealyticus: DSM 6717) and 20 clinical isolates (NRCS-A: 10) from England. Each genome is accompanied by minimum inhibitory concentrations of 13 antimicrobials including vancomycin, teicoplanin, daptomycin, linezolid, and clindamycin. These 22 genomes were 2.4-2.7 Mbp in length and had a GC content of 33%. Plasmids were identified in 20 isolates. Resistance to teicoplanin, daptomycin, gentamicin, fusidic acid, rifampicin, ciprofloxacin, clindamycin, and erythromycin was seen in 1-10 isolates. Our data are a resource for future studies on genomics, evolution, and antimicrobial resistance of S. capitis.

Indexed as

Anti-Bacterial AgentsGenome, BacterialStaphylococcus capitisDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsStaphylococcal InfectionsWhole Genome SequencingAnti-Bacterial AgentsAntibiogramsAntimicrobial resistanceAntimicrobial susceptibilityBioresourceGenomicsHybrid genome assemblyNanopore MinION sequencingNRCS-A cloneReference genomesStaphylococcus capitis

Identifiers

PMID39955481
PMCPMC11830182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.