Evidence map›Paper›PMID 39955452›Full record

ArticleInternational journal of computer assisted radiology and surgery2025

Breaking barriers: noninvasive AI model for BRAF

Fan Wu, Xiangfeng Lin, Yuying Chen, Mengqian Ge, Ting Pan, Jingjing Shi, Linlin Mao, Gang Pan, You Peng, Li Zhou and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. EnhancingQuantitative imaging in medicine and surgery · 2026
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fan Wu *Department of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Xiangfeng Lin *Department of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital, Qingdao University, Qingdao, Shandong Province, China.
Yuying Chen *The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Mengqian GeThe Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Ting PanDepartment of Pathology, Zhejiang Province People's Hospital, Hangzhou, 310014, Zhejiang, China.
Jingjing ShiDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Linlin MaoDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Gang PanDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
You PengDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Li ZhouDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China.
Haitao ZhengDepartment of Thyroid Surgery, The Affiliated Yantai Yuhuangding Hospital, Qingdao University, Qingdao, Shandong Province, China. zhenghaitao1972@126.com.
Dingcun LuoDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China. ldc65@163.com.
Yu ZhangDepartment of Oncological Surgery, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, 310006, Zhejiang, China. zhangyunjmu@126.com.

Funding

Medical Technology and Education of Zhejiang Province of China 2022KY939the Project of Medical Scientific and Technology Program in Hangzhou A20200432Zhejiang Provincial Natural Science Foundation of China under Grant LGF22H165705
6 · The paper itself

Abstract

objectiveBRAF MATERIALS AND

methodsRegions of interest (ROI) were manually annotated in the ultrasound images, and radiomic and DTL features were extracted. These were used in a joint DTL-radiomics (DTLR) model. Fourteen DTL models were employed, and feature selection was performed using the LASSO regression. Eight machine learning methods were used to construct predictive models. Model performance was primarily evaluated using area under the curve (AUC), accuracy, sensitivity and specificity. The interpretability of the model was visualized using gradient-weighted class activation maps (Grad-CAM).

resultsSole reliance on radiomics for identification of BRAF

conclusionThe ResNet152-based DTLR model demonstrated significant value in identifying BRAF

Indexed as

Artificial IntelligenceDeep LearningMutationProto-Oncogene Proteins B-rafThyroid Cancer, PapillaryThyroid NeoplasmsAdultFemaleHumansMachine LearningMaleMiddle AgedSensitivity and SpecificityUltrasonographyBRAF protein, humanProto-Oncogene Proteins B-rafBRAF V600EDeep learningPapillary thyroid carcinomaRadiomics

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.