ArticleScientific reports2025
Comprehensive analysis of the global, regional, and national burden of benign prostatic hyperplasia from 1990 to 2021.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Efficacy and safety of thulium fiber laser versus conventional holmium:YAG laser in anatomical endoscopic enucleation of the prostate: a systematic review and pairwise meta-analysis.World journal of urology · 2026Pooled it
- Ejaculation-sparing endoscopic surgery for benign prostatic hyperplasia: a systematic review and meta-analysis of randomized controlled trials.World journal of urology · 2026Pooled it
- Impact of laser power settings on sexual and urinary outcomes in holmium laser enucleation of the prostate: a multicenter randomized controlled trial.Lasers in medical science · 2025Trial
- How does PSA change after water vapor therapy? A systematic review and meta-analysis.Prostate cancer and prostatic diseases · 2026Review
- Global research landscape of natural medicines for lower urinary tract symptoms: bibliometric and clinical trial analysis.Tropical medicine and health · 2026Article
- From technical validation to functional preservation in robot-assisted simple prostatectomy: a bibliometric and thematic evolution analysis.Journal of robotic surgery · 2026Review
- Human biomarker navigator.iMeta · 2026Review
- Risk of New-Onset Postoperative Depression After Holmium Laser Enucleation Versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: A Nationwide Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Real-World Long-Term Outcomes of Rezūm Therapy for Large-Volume Benign Prostatic Hyperplasia: A Multicenter Cohort Study.Lower urinary tract symptoms · 2026Article
- Global stagnation and misaligned priorities in BPH drug development: a 25-year landscape analysis of clinical trial registries.npj aging · 2026Article
- Systemic Oxidative and Nitrosative Stress in Benign Prostatic Hyperplasia.Antioxidants (Basel, Switzerland) · 2026Article
- Prostate cancer and benign prostatic hyperplasia lesions segmentation using diffusion kurtosis imaging, T2*, and R2* mapping with U-Net++ algorithm.Radiological physics and technology · 2026Article
- Nutraceutical Effects ofNutrients · 2026Article
- Characterizing the academic literature on surgical management of benign prostatic hyperplasia: A bibliometric analysis.World journal of urology · 2026Article
- A Case Series on the Efficacy and Safety of Transperineal Laser Ablation for Benign Prostatic Hyperplasia.Journal of clinical medicine · 2026Article
- Urodynamic characteristics and clinical significance of detrusor overactivity in early (≤6 months) male urinary incontinence following TURP and RARP: a descriptive analysis of two cohorts.Frontiers in oncology · 2026Article
- Efficacy and safety of Serenoa repens in benign prostatic disorders: a systematic review of recent clinical evidence.Drugs in context · 2026Review
- Curcumin targets miR-21-3p: promising therapeutic strategy for treatment of benign prostatic hyperplasia.Molecular biology reports · 2025Article
- Rethinking LUTS/BPH/BPO management: the case for a multidisciplinary team approach.World journal of urology · 2025Article
- Educational value assessment of YouTube surgical videos of holmium laser enucleation of the prostate.World journal of urology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Benign prostatic hyperplasia (BPH) is a common urological condition affecting elderly men worldwide. In 2021, there were 112,502 (95% UI: 88,131.8-142,634.2) thousand prevalent cases globally, compared to 50,705.8 (95% UI: 38,735.5-65,693.4) thousand cases in 1990, representing a 122% increase. Over the past 30 years, the burden of BPH in low and low-middle socio-demographic index (SDI) regions have shown an upward trend and is projected to continue increasing over the next 15 years. Middle-SDI regions are facing the heaviest absolute burden of BPH. Despite declining prevalence, incidence, and disability-adjusted life years rates in high-middle SDI regions, the absolute BPH burden remains high, ranking second among the five SDI regions. In contrast, high-SDI regions exhibit a relatively low and stable BPH burden, though significant variations exist even among countries within the high-SDI category. Additionally, the global 65-69 age group bears the highest burden, with the 40-44 and 80+ age groups showing increasing trends. The burden of BPH varies significantly across regions, socioeconomic statuses, and countries, yet the absolute burden is generally increasing. The substantial regional differences in BPH burden underscore its widespread impact and potential controllability, indicating the need for more targeted healthcare efforts to address the growing BPH burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.