ArticleArchives of environmental contamination and toxicology2025
Quantification of Pesticides and In Vitro Effects of Water-Soluble Fractions of Agricultural Soils in South Africa.
Article in Archives of environmental contamination and toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Although agrochemicals protect crops and reduce losses, these chemicals can migrate to non-target environments via run-off and leaching following irrigation or heavy rainfall, where non-target organisms can be exposed to a mixture of water-soluble compounds. This study investigated whether the water-soluble fractions of selected agricultural soils from South Africa contain quantifiable concentrations of four commonly used pesticides, 2,4-dichlorophenoxyacetic acid (2,4-D), atrazine, dicamba and imidacloprid, and whether the aqueous extracts induce effects in vitro. Effects investigated included cytotoxicity using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell viability assay; xenobiotic metabolism using the H4IIE-luc rat hepatoma cell line; and (anti-)androgenic and (anti-)oestrogenic effects were screened for with the human breast carcinoma cell lines MDA-kb2 and T47D-KBluc, respectively. Oxidative stress responses were measured in H4IIE-luc and human duodenum adenocarcinoma (HuTu-80) cells. All extracts of soil induced oxidative stress, while several samples caused moderate to severe cytotoxicity and/or anti-androgenic effects. The herbicide atrazine had the greatest frequency of detection (89%), followed by dicamba (84%), 2,4-D (74%) and imidacloprid (32%). Concentrations of atrazine [2.0 × 10
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.