ArticleScientific reports2025
Joint analysis of time-varying effect of vaccine and antiviral drug for preventing severe complications and mortality.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
This study investigated the time-varying effects of vaccines and oral antiviral drugs in preventing severe COVID-19 complications and mortality in Hong Kong. Utilizing data from hospitalized patients diagnosed with SARS-CoV-2 between March 15, 2022, and November 30, 2022, the study employed the Andersen-Gill model with time-dependent explanatory variables to address immortal time bias. Results demonstrate that both vaccines and oral antivirals offered time-dependent protection, with vaccines showing significant waning effects after the fourth dose. Oral antivirals were most effective if administered within five days of diagnosis. Understanding these temporal effects is crucial for optimizing intervention strategies and improving clinical outcomes. The study also underscores the importance of considering pharmacodynamics and vaccination schedules in combating COVID-19.
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