ArticleScientific reports2025
The Burden of adolescent depression and the impact of COVID-19 across 204 countries and regions from 1990 to 2021: results from the 2021 global burden of disease study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Article
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- Psychological Interventions Targeting Depressive Symptoms in Children and Adolescents Living in War or Conflict Affected Zones: A Scoping Review.Current psychiatry reports · 2026Article
- Comparative effects of various exercise interventions on anxiety and depression symptoms in children and adolescents: a network meta-analysis of randomized controlled trials.European child & adolescent psychiatry · 2026Review
- Does healthcare expenditure matter equally for all mental disorders? An international approach employing dynamic panel data methods.Cost effectiveness and resource allocation : C/E · 2026Article
- Trends and projections of PMFrontiers in public health · 2026Article
- Augmented reality-based fine arts education experiences and adolescents' perceived reduction in depressive symptoms: a self-report study of associations with psychological resilience, rumination, and emotional regulation.Frontiers in psychiatry · 2026Article
- The effects of group nursing intervention based on emotion regulation training on depression and nonsuicidal self-injury in adolescents.BMC psychology · 2025Article
- Ten-year trends in opioid prescribing and vaso-occlusive crises in sickle cell disease: a population-based national cohort study (2011-2022).Lancet regional health. Americas · 2025Article
- Multimodal evaluation of nitazoxanide as an antidepressant: behavioral, biochemical, and molecular docking insights.Metabolic brain disease · 2025Article
- Agomelatine Alleviates Depressive-like Behaviors by Suppressing Hippocampal Oxidative Stress in the Chronic Social Defeat Stress Model.Antioxidants (Basel, Switzerland) · 2025Article
- Advances in the prevalence and treatment of depression for adolescents: a review.Frontiers in pharmacology · 2025Review
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8 authors.
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Abstract
This study aims to analyze the trends in the burden of depression among adolescents aged 10 to 24 years globally from 1990 to 2021, with a focus on the impact of COVID-19 on adolescent depression and health inequalities. Using data from the 2021 Global Burden of Disease Study, we examined age-standardized prevalence, incidence, and disability-adjusted life years (DALYs) for depression among adolescents aged 10-24 years. Estimated annual percentage change (EAPC) was used to assess temporal trends. Age-period-cohort (APC) analysis estimated age, period, and cohort effects. Bayesian APC (BAPC) analysis projected future trends. Decomposition analysis further explored drivers of changes in depression burden. Slope Index of Inequality (SII) and Concentration Index (CI) were calculated to assess health inequalities across regions and countries. From 1990 to 2021, the global incidence, prevalence and DALY rates of adolescent depression remained stable. Depression incidence and prevalence increased with age, with the 20-24 age group showing the highest rates. The burden of depression was higher in females than in males. The COVID-19 pandemic significantly impacted adolescent depression, with reported prevalence, incidence, and DALY rates in 2020 and 2021 far exceeding predicted values, and the burden of depression is expected to continue rising. Health inequalities between adolescents in high- and low-income regions have widened, particularly following the pandemic. The COVID-19 pandemic significantly exacerbated the burden of depression and intensified health inequalities.
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