ArticleNature communications2025
Janus decellularized membrane with anisotropic cell guidance and anti-adhesion silk-based coatings for spinal dural repair.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- 3D-Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair.Cell proliferation · 2026Review
- Xylem-inspired anisotropic porous silk microneedles enable efficient interstitial fluid sampling for local biomarker and proteomic profiling of skin diseases.Materials today. Bio · 2026Article
- Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time-Programmable Anti-Infective Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- An Asymmetric Dura-Inspired Collagen Hydrogel Patch with Integrated Dense-Porous Architecture Enabled by Dual-Channel Freeze Casting.Advanced healthcare materials · 2026Article
- Bispecific antibody engineered extracellular vesicles redirect T cells to prevent postoperative epidural fibrosis.Nature communications · 2026Article
- A stage-based framework for closed-loop recycling of polymeric composite membranes.Science advances · 2026Article
- High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential.Materials today. Bio · 2026Review
- Biosafe macromolecular crosslinking enables tunable biodegradation and sustained reparative bioactivity of small intestinal submucosa.Materials today. Bio · 2026Article
- Targeting the glial-fibrotic scar microenvironment after spinal cord injury: From integrated protection to systematic regulation of regenerative balance.Journal of orthopaedic translation · 2026Review
- A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.Bioactive materials · 2026Article
- Efficacy of nano-silver small intestine submucosa repair of osteochondral defect in rabbit model by the AMPK-mTOR-ULK1 pathway.Hereditas · 2026Article
- Multifunctional Janus Hydrogels: Surface Design Strategies for Next-Generation Clinical Solutions.Gels (Basel, Switzerland) · 2025Review
- Hydrogel-Based Biomaterials in Spinal Repair: Evaluating Mechanisms for IVDD, SCI, and Dural Regeneration.Journal of multidisciplinary healthcare · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The repair of soft tissues with anisotropic structures, such as spinal dura mater, requires the use of biomaterials to guide tissue directional growth while minimizing epidural fibrotic adhesion. Herein, we construct the Janus small intestinal submucosa (SIS) via silk-based hydrogel coatings, which provides extracellular matrix-mimicking features and anti-adhesion performance for spinal dural defect repair. We demonstrate that the silk fibroin and methacrylated silk fibroin (SilMA) composite microgroove hydrogel coating at the inner surface via water vapor annealing treatment exhibits excellent structure stability, stable attachment to SIS substrate, and shows orientated cell morphology and extracellular matrix produced by fibroblasts, good histocompatibility and promotes the polarization of macrophages towards the anti-inflammatory phenotype. The methacrylated hyaluronic acid and SilMA composite coating outer surface serves as favorable physical barrier shows effective resistance to protein adsorption, cell and tissue adhesion, and can mitigate fibrosis reactions. Spinal dura mater defect experiments on male rats demonstrate that the Janus SIS simultaneously promotes dural regeneration and inhibits epidural fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.