Evidence map›Paper›PMID 39955068›Full record

SynthesisJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

Late gadolinium-enhanced cardiovascular magnetic resonance for predicting left ventricular reverse remodeling in dilated cardiomyopathy: A comprehensive review and meta-analysis.

Yaqiong Zhou, Yuanwei Xu, Yangjie Li, Chuang Huang, Yucheng Chen

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Yaqiong ZhouDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Department of Cardiology, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan Province, China; Cardiac Imaging and Target Therapy Lab, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yuanwei XuDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Cardiac Imaging and Target Therapy Lab, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yangjie LiDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Cardiac Imaging and Target Therapy Lab, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Chuang HuangDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Cardiac Imaging and Target Therapy Lab, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Yucheng ChenDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Cardiac Imaging and Target Therapy Lab, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. Electronic address: Chenyucheng2003@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is currently a lack of evidence regarding the significance of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) in predicting left ventricular (LV) reverse remodeling (RR) in pooled data. This study aimed to evaluate the predictive value of the presence and extent of LGE for LVRR in patients with dilated cardiomyopathy (DCM).

methodsSystematic searches were conducted in PubMed, Embase, Cochrane Library, and ClinicalTrials.gov from database inception to May 21, 2024. We estimated the overall effect sizes using the Mantel-Haenszel random-effects model. Subgroup analyses, meta-regression, and sensitivity analyses were performed to investigate potential sources of heterogeneity among studies.

resultsA total of 1141 patients (LGE prevalence: 49.7% (567/1141)) from 13 studies (5 prospective and 8 retrospective) were included. After a median follow-up period of 15 months, 43.5% of patients achieved LVRR. The presence of LGE predicted LVRR with a pooled odds ratio (OR) of 0.23 (95% confidence interval [CI]: 0.14-0.38, P < 0.01) with significant heterogeneity (I

conclusionThe presence and increase extent of LGE on CMR significantly diminish LVRR achievement in DCM patients, particularly in short-term follow-up (<12 months).

Indexed as

Cardiomyopathy, DilatedContrast MediaGadoliniumMagnetic Resonance ImagingMagnetic Resonance Imaging, CineVentricular Function, LeftVentricular RemodelingAdultAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisRecovery of FunctionContrast MediaGadoliniumCardiac magnetic resonanceDilated cardiomyopathyLate gadolinium enhancementReverse remodeling

Identifiers

PMID39955068
PMCPMC12151184

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.