Evidence map›Paper›PMID 39954950›Full record

ReviewClinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases2025

Disseminated Saccharomyces cerevisiae infection in advanced HIV: a literature review.

Lucy X Li, Amita Gupta, Matthew M Hamill, Sean X Zhang, Yukari C Manabe

Abstract readReviewCase Reports
In one paragraph

Review in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Phylogenomic diversity of clinicalMicrobiology spectrum · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lucy X LiDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: lli101@jh.edu.
Amita GuptaDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Matthew M HamillDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sean X ZhangDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yukari C ManabeDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
TrainingU54EB007958 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Yukari C Manabe, Susan Anne Tuddenham · 2007 to 2026
$34.6M
RESEARCH TRAINING IN MICROBIAL DISEASEST32AI007291 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JOEL N BLANKSON, Sara Elizabeth Cosgrove · 1986 to 2026
$9.1M
NIAID NIH HHS P30 AI094189NIAID NIH HHS T32 AI007291NIAID NIH HHS UM1 AI068613NIBIB NIH HHS U54 EB007958
6 · The paper itself

Abstract

backgroundSaccharomyces cerevisiae is a common environmental fungus and an uncommon, but increasingly recognized, cause of invasive fungal infection. The clinical manifestations of this infection can often be mistaken for histoplasmosis, a major cause of mortality in patients with advanced HIV.

objectivesThis study aims to review the current epidemiology, diagnostic approaches, and management strategies for S. cerevisiae infection in patients with HIV. SOURCES: A literature search was conducted using PubMed from January 1980 and May 2024. CONTENT: This review features a case of S. cerevisiae infection in a patient with HIV to highlight the diagnostic challenges and clinical implications of disseminated infection. A summary of published cases in patients with vs. without HIV is provided alongside a review and discussion of both conventional and novel diagnostic methods. The role of current antifungal therapies in managing S. cerevisiae infections is also examined. IMPLICATIONS: S. cerevisiae is a rare but clinically important opportunistic pathogen in patients with advanced HIV who have epidemiological risk factors. When found in mucocutaneous lesions under the appropriate clinical scenario, S. cerevisiae should not automatically be dismissed as commensal flora.

Indexed as

AIDS-Related Opportunistic InfectionsHIV InfectionsInvasive Fungal InfectionsSaccharomyces cerevisiaeAntifungal AgentsHumansMaleAntifungal AgentsInvasive fungal infectionSaccharomyces cerevisiae

Identifiers

PMID39954950
PMCPMC12003043

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.