Evidence map›Paper›PMID 39954533›Full record

Trial reportThe journal of nutrition, health & aging2025

Long-term frailty and physical performance transitions in older people with type-2 diabetes. The MIDFRAIL randomized clinical study.

Olga Laosa, Eva Topinkova, Isabelle Bourdel-Marchasson, Bruno Vellas, Mikel Izquierdo, Giusseppe Paolisso, Timothy Hardman, Andrej Zeyfang, Laura Pedraza, Jose A Carnicero and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The journal of nutrition, health & aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01654341 (A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN FRAIL AND PREFRAIL OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01654341 nacompletednot on this map

A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN FRAIL AND PREFRAIL OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-Frail STUDY

TypeinterventionalSponsorHospital Universitario GetafeRan2013 to 2017Enrolled986ConditionsType 2 Diabetes MellitusArmsExercise, dietary and educational program
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Olga LaosaFoundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain; Biomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain.
Eva TopinkovaFirst Faculty of Medicine, Charles University, Prague, Czech Republic.
Isabelle Bourdel-MarchassonCentre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Bruno VellasCentre Hospitalier Universitaire de Toulouse, Toulouse, France.
Mikel IzquierdoIdiSNA, Navarra Institute for Health Research, Public University of Navarra, Pamplona, Spain.
Giusseppe PaolissoUniversity of Campania-Luigi Vanvitelli, Naples, Italy.
Timothy HardmanNiche Science and Technology Ltd, Richmond, United Kingdom.
Andrej ZeyfangUlm University, Ulm, Germany.
Laura PedrazaFoundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain.
Jose A CarniceroFoundation for Biomedical Research-University Hospital of Getafe, Madrid, Spain.
Leocadio Rodriguez-MañasBiomedical Research Center Network for Frailty and Healthy Ageing (CIBERFES), Institute of Health Carlos III, Madrid, Spain; Department of Geriatrics, University Hospital of Getafe, Madrid, Spain. Electronic address: leocadio.rodriguez@salud.madrid.org.
Alan J SinclairFoundation for Diabetes Research in Older People (fDROP), and Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College, London, United Kingdom.
MIDFRAIL consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsType 2 diabetes (T2D) is associated with frailty in older people. We aim to explore changes in frailty status after ≥18 months of intervention.

methods298 community-dwelling older adults (>70 years) participating in MIDFRAIL followed-up for 18-24 months were randomly allocated by trial site (cluster) to intervention IG (16-weeks resistance exercise program, nutritional-educational sessions, optimization of diabetes care), or usual care group (UCG). Frailty status was assessed by the Fried Frailty Phenotype criteria at baseline and final visit. Functional status was assessed by the SPPB in every visit. We used multivariate linear and logistic regression for continuous and dichotomous outcomes. This study was registered at Clinicaltrials.gov (NCT01654341).

resultsMean age was 77.7 (SD 5.54), 47% were male, 32.9% frail and 67.1% prefrail. The probability of improving the frailty status and decreasing the number of Fried's frailty criteria was higher in the IG than in the UCG (OR 2.6, 95%CI 1.3-5.4; p = 0.009 and OR 1.9; 95%CI 1.1-3.1; p = 0.02, respectively). IG participants more frequently improved ≥1 point in SPPB score (OR 1.85; 95%CI 1.09-3.12; p = 0.022). These benefits were mainly accounted for the prefrail participants.

conclusionsThe MIDFRAIL intervention improved frailty status and physical function at long-term follow-up in older people with T2D.

Indexed as

Diabetes Mellitus, Type 2Frail ElderlyFrailtyPhysical Functional PerformanceAgedAged, 80 and overFemaleGeriatric AssessmentHumansIndependent LivingMaleResistance TrainingClinical trialDiabetesFrailtyFunctional impairmentOlder people

Identifiers

PMID39954533
PMCPMC12179999

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.