Evidence map›Paper›PMID 39954250›Full record

ArticleCell reports2025

Yeast TIA1 coordinates with Npl3 to promote ATG1 translation during starvation.

Shree Padma Metur, Xinxin Song, Sophie Mehta, Dimitra Dialynaki, Dibyendu Bhattacharyya, Zhangyuan Yin, Daolin Tang, Daniel J Klionsky

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Shree Padma MeturLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Xinxin SongDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Sophie MehtaLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Dimitra DialynakiLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.
Dibyendu BhattacharyyaLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.
Zhangyuan YinLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Daolin TangDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: klionsky@umich.edu.

Funding

ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1M
The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
Targeting HMGB1-mediated Autophagy in Cancer TherapyR01CA160417 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2012 to 2023
$3.0M
Mechanisms of Ferroptotic Cancer Cell DeathR01CA229275 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI TANG, DAOLIN · 2019 to 2024
$1.8M
NCI NIH HHS R01 CA160417NCI NIH HHS R01 CA229275NIGMS NIH HHS R01 GM053396NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Macroautophagy/autophagy is crucial for cell survival during nutrient starvation. Autophagy requires the coordinated function of several Atg proteins, including the Atg1 kinase, for efficient induction and execution. Recently, several RNA-binding proteins (RBPs) have been shown to post-transcriptionally regulate ATG1. However, a comprehensive understanding of autophagy regulation by RBPs via ATG1 is yet to be elucidated. Here, we utilize an in vitro approach to identify RBPs that specifically interact with ATG1 untranslated regions. We show that Npl3 and Pub1 interact with the ATG1 5' and 3' untranslated regions during nitrogen starvation. Furthermore, Npl3 and Pub1 coordinate to facilitate ATG1 mRNA export to the cytoplasm and its subsequent interaction with the translational machinery. Significantly, in non-small cell lung cancer cell lines, mammalian Pub1, TIA1, also positively regulates ULK1 protein expression and autophagy during serum starvation. Overall, our study highlights the regulatory landscape that fine-tunes Atg1 protein expression to sustain autophagy during nutrient starvation.

Indexed as

Autophagy-Related Protein-1 HomologAutophagy-Related ProteinsNuclear ProteinsProtein BiosynthesisRNA-Binding ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsT-Cell Intracellular Antigen-1AutophagyHumansProtein KinasesRNA, MessengerATG1 protein, S cerevisiaeAutophagy-Related Protein-1 HomologAutophagy-Related ProteinsNuclear ProteinsProtein KinasesRNA-Binding ProteinsRNA, MessengerSaccharomyces cerevisiae ProteinsT-Cell Intracellular Antigen-1autophagyCP: Cell biologyCP: Molecular biologymacroautophagymammalian cellsmRNA metabolismpost-transcriptional regulationRBPsstresstranslationyeast

Identifiers

PMID39954250
PMCPMC11913251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.