Evidence map›Paper›PMID 39954214›Full record

ReviewCurrent pain and headache reports2025

Update on Neuromodulation for Migraine and Other Primary Headache Disorders: Recent Advances and New Indications.

Alexandra N Cocores, Liza Smirnoff, Guy Greco, Ricardo Herrera, Teshamae S Monteith

Abstract readReview
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
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  5. Review
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra N CocoresDepartment of Neurology─Headache Division, University of Miami, Miller School of Medicine, 1120 NW 14Th Street, 13th floor, Miami, FL, 33136, USA.
Liza SmirnoffDepartment of Neurology─Headache Division, University of Miami, Miller School of Medicine, 1120 NW 14Th Street, 13th floor, Miami, FL, 33136, USA.
Guy GrecoDepartment of Neurology─Headache Division, University of Miami, Miller School of Medicine, 1120 NW 14Th Street, 13th floor, Miami, FL, 33136, USA.
Ricardo HerreraDepartment of Neurology─Headache Division, University of Miami, Miller School of Medicine, 1120 NW 14Th Street, 13th floor, Miami, FL, 33136, USA.
Teshamae S MonteithDepartment of Neurology─Headache Division, University of Miami, Miller School of Medicine, 1120 NW 14Th Street, 13th floor, Miami, FL, 33136, USA. tmonteith@med.miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewNeuromodulation techniques currently available for headache management are reviewed in this article, with a focus on recent advances in non-invasive devices for migraine and trigeminal autonomic cephalalgias. RECENT

findingsThe currently available FDA-cleared non-invasive devices for migraine include transcutaneous supraorbital and supratrochlear nerve stimulation, single-pulse transcranial magnetic stimulation (sTMS), external concurrent occipital and trigeminal neurostimulation (eCOT-NS), remote electrical neuromodulation (REN), and non-invasive vagal nerve stimulation (nVNS) with indications for migraine and trigeminal autonomic cephalalgias. Emerging non-invasive techniques being explored for use in migraine include transcranial direct current stimulation (tDCS), kinetic oscillation stimulation (KOS), and auricular transcutaneous vagal nerve stimulation (at-VNS). In addition to primary headache, non-invasive neuromodulation is being investigated for comorbid conditions such as depression. Non-invasive neuromodulation devices remain a safe, well-tolerated, and effective therapy for patients with primarily migraine and trigeminal autonomic cephalalgias. Ongoing research is needed to determine efficacy in other headache disorders and comorbid conditions.

Indexed as

Electric Stimulation TherapyHeadache Disorders, PrimaryMigraine DisordersHumansTranscranial Direct Current StimulationTranscranial Magnetic StimulationTranscutaneous Electric Nerve StimulationVagus Nerve StimulationCluster headacheMigraine headache disorderNeuromodulationNon-invasive deviceNon-pharmacologic treatmentPrimary headache disorder

Identifiers

PMID39954214
PMCPMC11829934

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.