Evidence map›Paper›PMID 39954195›Full record

ArticleJournal of endocrinological investigation2025

Stratified analysis of health and gender-affirming care among Italian transgender and gender diverse adults.

Matteo Marconi, Angela Ruocco, Jiska Ristori, Stefania Bonadonna, Rosario Pivonello, Maria Cristina Meriggiola, Giovanna Motta, Francesco Lombardo, Maddalena Mosconi, Alessandro Oppo and 14 more

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In one paragraph

Article in Journal of endocrinological investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Matteo MarconiReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Angela RuoccoReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Jiska RistoriAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy.
Stefania BonadonnaIstituto Auxologico Italiano, IRCCS, Milan, Italy.
Rosario PivonelloDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University Federico II, Naples, Italy.
Maria Cristina MeriggiolaDivision of Gynecology and Physiopathology of Human Reproduction, Department of Medical and Surgical Sciences (DIMEC), S. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.
Giovanna MottaDivision of Endocrinology, Diabetology and Metabolism, Azienda Ospedaliero- Universitaria Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
Francesco LombardoLaboratory of Semiology, Sperm Bank Loredana Gandini, Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Maddalena MosconiGender Identity Development Service, Hospital S. Camillo-Forlanini, Rome, Italy.
Alessandro OppoEndocrinology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Silvia FedericiIstituto Auxologico Italiano, IRCCS, Milan, Italy.
Luca BrunoDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University Federico II, Naples, Italy.
Nunzia VerdeDipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, University Federico II, Naples, Italy.
Alessandra LamiDivision of Gynecology and Physiopathology of Human Reproduction, Department of Medical and Surgical Sciences (DIMEC), S. Orsola Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Bologna, Italy.
Chiara Michela CrespiDivision of Endocrinology, Diabetology and Metabolism, Azienda Ospedaliero- Universitaria Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
Martina ManoliReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Paola MatarreseReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Carmela SantangeloReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Luciana GiordaniReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy.
Maria Teresa PaganoDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Cristiana BarbatiDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Sara D'ArienzoTuscany Central Local Health Company, Florence, Tuscany, Italy.
Alessandra Daphne FisherAndrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, Florence, Italy.
Marina PierdominiciReference Centre for Gender Medicine, Istituto Superiore di Sanità, Rome, Italy. marina.pierdominici@iss.it.ORCID http://orcid.org/0000-0002-6372-3754

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to provide the first comprehensive analysis of the health status of transgender and gender-diverse (TGD) adults in Italy, addressing disparities in physical and mental health and access to gender-affirming care. By combining self-reported health data with clinical evaluations and incorporating demographic and clinical variables, the research offers a robust and previously unavailable health profile of this population.

methodsAn anonymous online survey targeting TGD adults across Italy was conducted from June 2020 to June 2021. The survey consisted of self-reported health assessments and clinician-conducted evaluations, collecting data on chronic physical conditions, mental health disorders, infectious diseases, and gender-affirming care. Statistical analyses, including chi-square tests and logistic regression, identified associations between demographics and health outcomes.

resultsAmong 959 participants, mental health disorders were prevalent, with over half experiencing depression and/or anxiety. Non-binary individuals reported poorer health compared to binary individuals. Chronic conditions such as thyroid disorders were more common in individuals assigned female at birth (AFAB), whereas those assigned male at birth (AMAB) had higher rates of osteoporosis and sexually transmitted infections. Key health predictors included age, education, employment, and engagement in gender-affirming hormone therapy.

conclusionThe study reveals stark health disparities among TGD individuals in Italy, emphasizing the need for targeted health policies, expanded mental health services, and specialized healthcare provider training.

Indexed as

Gender-Affirming ProceduresHealth StatusMental DisordersTransgender PersonsAdolescentAdultFemaleGender-Affirming CareHealthcare DisparitiesHumansItalyMaleMiddle AgedSurveys and QuestionnairesYoung AdultChronic diseaseGender identityHealthcare disparitiesMental healthNon-binaryTransgender

Identifiers

PMID39954195

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.