ArticleFish physiology and biochemistry2025
Promoting adipocyte hyperplasia ameliorates high-carbohydrate diet-induced inflammation, oxidative stress, and metabolic disorders and enhances growth performance and immune function in grass carp (Ctenopharyngodon idellus).
Article in Fish physiology and biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Inducing adipocyte hyperplasia improves growth performance, alleviates hepatic steatosis and counteracts muscle quality deterioration in largemouth bass (Micropterus salmoides) fed with high-carbohydrate diet.Fish physiology and biochemistry · 2026Article
- Comparative Transcriptome Analysis of Orbital Fat Reveals Stage-Specific Gene Expression Associated with Growth Variation in Bighead Carp (Animals : an open access journal from MDPI · 2026Article
- Hypoxia-inducible factor 1αa regulates lipid metabolism to coordinate adipocyte hypertrophy and hyperplasia in grass carp.The Journal of biological chemistry · 2026Article
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9 authors.
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Abstract
Addressing the adverse effects of high-carbohydrate diets (HCD) on fish growth and health has been a critical area of aquaculture research, as it remains a key factor limiting the broader application of HCD in the industry. Recent studies have focused on the liver mechanisms involved in HCD-induced challenges, while limited attention has been given to adipose tissue. This study investigated the impact of enhancing adipocyte hyperplasia on growth performance, immunity, antioxidative capacity, inflammation, and metabolism in grass carp (Ctenopharyngodon idellus) subjected to an HCD. Rosiglitazone (R), a peroxisome proliferator-activated γ agonist, was used to promote adipocyte hyperplasia. A total of 225 grass carp (initial body weight, 19.05 ± 0.06 g) were divided into three groups (control, HCD, and HCD + R) and fed for 8 weeks, with three replicates per group. The findings indicated that HCD induced inflammation, fibrosis, and metabolic disorders in adipose tissue, which were significantly alleviated following the promotion of adipocyte hyperplasia (P < 0.05). Improvement in the health status of adipose tissue resulted in a significant reduction in the pro-inflammatory cytokine interleukin-1β (IL-1β) produced and secreted by adipose tissue. In contrast, IL-1 receptors and downstream related genes in the liver and muscle were significantly downregulated (P < 0.05). Furthermore, promoting adipocyte hyperplasia alleviated hepatic steatosis and enhanced muscle protein synthesis. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglycerides (TG), glucose (GLU), and lactate dehydrogenase (LDH) returned to normal after promoting adipocyte hyperplasia. Notably, promoting adipocyte hyperplasia enhanced anti-oxidant enzyme activities in the serum and significantly improved immune function in the grass carp (P < 0.05). These enhancements contributed to improved growth performance and feed efficiency. Conclusively, modifying the pattern of adipose tissue expansion by promoting adipocyte hyperplasia mitigated the adverse effects of HCD on health and growth performance while enhancing both anti-oxidant and immune capacities in grass carp.
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