Evidence map›Paper›PMID 39954184›Full record

ArticleJournal of gastrointestinal cancer2025

Racial/Ethnic Differences and Effects of Clinical/Socioeconomic Factors on Time from Diagnosis to Treatment in Pancreatic Cancer.

Anush Sridharan, Efrat Dotan, Marianna Dorta, Navya Vemula, Elizabeth Handorf, Mengying Deng, Ashley Renning, Kristen Sorice, Lauren Laderman, Kate Whittington and 6 more

Abstract read
In one paragraph

Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Anush SridharanDepartment of Medical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Efrat DotanFox Chase Cancer Center, Cancer Prevention and Control, Young Pavilion P4159, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Marianna DortaLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Navya VemulaLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Elizabeth HandorfPopulation Studies Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Mengying DengPopulation Studies Facility, Fox Chase Cancer Center, Philadelphia, PA, USA.
Ashley RenningFox Chase Cancer Center, Cancer Prevention and Control, Young Pavilion P4159, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Kristen SoriceFox Chase Cancer Center, Cancer Prevention and Control, Young Pavilion P4159, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Lauren LadermanLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Kate WhittingtonFox Chase Cancer Center, Cancer Prevention and Control, Young Pavilion P4159, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Edna CukiermanProgram of Cancer Signaling and Epigenetic, Fox Chase Cancer Center, Philadelphia, PA, USA.
Igor AstsaturovDepartment of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Namrata VijayvergiaFox Chase Cancer Center, Cancer Prevention and Control, Young Pavilion P4159, 333 Cottman Avenue, Philadelphia, PA, 19111, USA.
Joshua E MeyerDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Sanjay S ReddyDepartment of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Shannon M LynchLewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. Shannon.lynch@fccc.edu.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Pancreatic Cancer-Associated Fibroblasts: Function, Detection, and RegulationR01CA269660 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Edna Cukierman · 2022 to 2026
$3.1M
NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA269660
6 · The paper itself

Abstract

purposeFive-year survival for pancreatic adenocarcinoma (PDAC) is < 10% but can vary by a patient's race, socioeconomic status (SES), and the factors related to the neighborhood where a patient lives (nSES) . Prolonged time from diagnosis to first treatment (T2T) is another important disparity indicator. Here, we examined the effect of race, nSES, and patient-level clinical factors on T2T and survival in metastatic PDAC (mPDAC) patients.

methodsPatients with mPDAC treated at an academic cancer center between 2010 and 2018 (n = 334) were evaluated for nSES measures related to racial concentration, neighborhood deprivation, stability, immigration status, and transportation access from the US Census. We assessed and reported the effects of nSES and patient-level variables (age, race, gender, Charlson Comorbidity Index (CCI), etc.) on T2T and survival using univariate and multivariate Cox proportional hazards regression, hazard ratios (HR), confidence intervals (CI).

results82.9% of the patients were White; 17.1% were Black. Median T2T was 26 days with no significant difference in T2T and survival by race. In multivariable models, no nSES variables were significantly associated with T2T. T2T did not significantly impact survival; however, receipt of chemotherapy (HR = 0.14 [95% CI = 0.06, 0.30]) was associated with better survival outcomes.

conclusionAmong patients with mPDAC, T2T was not associated with race/ethnic disparities or survival in a mostly White, high SES population treated at a comprehensive cancer center. Future investigations into pancreatic cancer disparities may be warranted in other hospital settings and in larger, more diverse study samples.

Indexed as

Healthcare DisparitiesPancreatic NeoplasmsTime-to-TreatmentAgedAged, 80 and overEthnicityFemaleHumansMaleMiddle AgedRacial GroupsRetrospective StudiesSocioeconomic FactorsHealth disparitiesNeighborhoodPancreatic cancerSocial determinantsSurvival

Identifiers

PMID39954184
PMCPMC11829832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.