Evidence map›Paper›PMID 39954177›Full record

ArticleBulletin of experimental biology and medicine2025

Studying the Influence of Ischemic Liver Damage on the Pharmacokinetics of a Phenolic Antioxidant.

E A Yanovskaya, G A Frelikh, A P Lakeev, G A Chernysheva, V I Smolyakova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E A YanovskayaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia. elena.yanovskaya@pharmso.ru.
G A FrelikhGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
A P LakeevGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
G A ChernyshevaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
V I SmolyakovaGoldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new approach has been developed to study the pharmacokinetics of 2,6-diisobornyl-4-methylphenol, a phenolic antioxidant, after intragastric administration at a dose of 10 mg/kg to male Wistar rats with ischemia/reperfusion liver injury. The control group consisted of rats without pathology. A catheter previously implanted into the jugular vein of the animals, allowed repeated blood sampling and monitoring of the pharmacokinetic profile of the substance in each animal. Pharmacokinetic studies usually involve healthy animals, but the ischemia/reperfusion injury of the liver disrupted its functions, potentially altering drug metabolism and pharmacokinetics. Analysis of actual blood plasma samples confirmed the effectiveness of the proposed approach: changes in the pharmacokinetics of the phenolic antioxidant were revealed during liver ischemia/reperfusion injury in rats.

Indexed as

AntioxidantsCamphanesLiverPhenolsReperfusion InjuryAnimalsMaleRatsRats, WistarAntioxidantsCamphanesPhenols2,6-diisobornyl-4-methylphenolcatheterizationischemia/reperfusionliverpharmacokinetics

Identifiers

PMID39954177

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.