Evidence map›Paper›PMID 39954176›Full record

ArticleBulletin of experimental biology and medicine2025

Effect of Breathing a Krypton-Oxygen Mixture on Signaling Cascades in Rat Brain during Simulation of Photoinduced Ischemic Stroke.

V V Antonova, I V Shumov, V T Dolgikh, A A Grebenchikova, M V Gabitov, E I Yakupova, O A Grebenchikov

Abstract read
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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

V V AntonovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia. victoryant.sci@gmail.com.
I V ShumovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia.
V T DolgikhFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia.
A A GrebenchikovaFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia.
M V GabitovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia.
E I YakupovaA. N. Belozersky Research Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.
O A GrebenchikovFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, V. A. Negovsky Research Institute of General Reanimatology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of a krypton-oxygen mixture on the key signaling pathways associated with ischemic tolerance and suppression of secondary damage in a model of photoinduced stroke in male Wistar rats. In animals breathing the krypton-oxygen mixture, the expression of the transcription factor NF-κB (p50) in the brain was suppressed, indicating anti-inflammatory shifts in the brain tissue upon exposure to krypton, in parallel, increased content of phosphorylated forms of glycogen synthase kinase 3β (GSK-3β) and protein kinase B (Akt), components of the preconditioning cascade, was revealed. These results indicate a high potential of krypton in reducing acute cerebral disorders.

Indexed as

BrainIschemic StrokeOxygenAnimalsGlycogen Synthase Kinase 3 betaMaleNF-kappa BPhosphorylationProto-Oncogene Proteins c-aktRatsRats, WistarSignal TransductionGlycogen Synthase Kinase 3 betaNF-kappa BOxygenProto-Oncogene Proteins c-aktGSK-3βkryptonneuroprotective effectphotochemically induced strokestroke

Identifiers

PMID39954176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.