Evidence map›Paper›PMID 39954163›Full record

ArticleMolecular neurobiology2025

Autophagy Induction by Mangiferin Protects Auditory Hair Cells from Ototoxicity.

Gyeong Min Lim, Gwang-Won Cho, Chul Ho Jang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gyeong Min Lim *Department of Biological Science, College of Natural Science, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju, 61452, Republic of Korea.
Gwang-Won Cho *Department of Biological Science, College of Natural Science, Chosun University, 309 Pilmun-Daero, Dong-Gu, Gwangju, 61452, Republic of Korea.
Chul Ho JangDepartment of Otolaryngology, Gwangju Veterans Hospital, Gwangju, 62284, Republic of Korea. chulsavio@hanmail.net.

Funding

National Research Foundation of Korea RS-2023-00285353
6 · The paper itself

Abstract

Oxidative stress is a major cause of auditory hair cell degeneration and hearing impairment.Reducing intracellular reactive oxygen species (ROS) levels may help preserve auditory hair cell function. In this study, we explored the otoprotective properties of mangiferin, a xanthonoid extracted from mango leaves, bark, and fruit peels. Our findings indicate that mangiferin protects HEI-OC1 cells against oxidative stress induced by H

Indexed as

AutophagyHair Cells, AuditoryOtotoxicityXanthonesAnimalsCell LineEvoked Potentials, Auditory, Brain StemFurosemideGuinea PigsHydrogen PeroxideKanamycinMaleOxidative StressProtective AgentsRatsRats, Sprague-DawleyFurosemideHydrogen PeroxideKanamycinmangiferinProtective AgentsReactive Oxygen SpeciesXanthonesAutophagyHearing lossMangiferinOtotoxicityOxidative stress

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.