ArticleArchives of dermatological research2025
METTL3-modified exosomes from adipose-derived stem cells enhance the proliferation and migration of dermal fibroblasts by mediating m6A modification of CCNB1 mRNA.
Article in Archives of dermatological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Exosomes in precision dermatology: From biomarkers to targeted therapeutics in personalized care.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Review
- METTL3-driven mJournal of translational medicine · 2026Article
- Exosome-Mediated Rewiring of Oxidative Stress-Inflammation-ECM Remodeling Axis Mitigates UVB-Triggered Skin Photoaging.International journal of nanomedicine · 2026Review
- RNA modifications: molecular orchestrators of wound healing.Burns & trauma · 2026Article
- WTAP-mediated mHuman cell · 2025Article
- Transdermal Drug Delivery Systems: Methods for Enhancing Skin Permeability and Their Evaluation.Pharmaceutics · 2025Review
- Review
- Investigate the co-culture effects of BM-mesenchymal stem cells on the promotion of apoptotic pathways of CD34BioImpacts : BI · 2025Article
- Targeting adipocyte differentiation with CRT0066101: activation of AMPK signaling in 3T3-L1 cells.Frontiers in pharmacology · 2025Article
- Research Hotspots in Natural Products for Wound Healing: A Bibliometric Analysis and Literature Review.Clinical, cosmetic and investigational dermatology · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Skin scalded injury is a devastating condition. Exosomes derived from adipose-derived mesenchymal stem cells (ASC-exos) have been shown encouraging therapeutic potential in wound healing. Here, we explored the activity and mechanism of methyltransferase-like 3 (METTL3)-modified ASC-exos in the migration and proliferation of dermal fibroblasts. ASC-exos were isolated from mouse ASCs, characterized, and used to incubate mouse dermal fibroblasts. Fluorescence microscopy was used to analyze the transfer of ASC-exos into fibroblasts. Cell migration, invasion, proliferation, and viability were assessed by wound healing, transwell, 5-Ethynyl-2'-deoxyuridine (EdU), and Cell Counting Kit-8 (CCK-8) assays, respectively. Protein expression was tested by western blotting. The influence of METTL3 in cyclin B1 (CCNB1) was evaluated by methylated RNA immunoprecipitation (MeRIP), actinomycin D treatment and quantitative PCR assays. ASC-exos significantly increased the proliferative, invasive, and migratory potentials of dermal fibroblasts. Overexpression of METTL3 resulted in elevated proliferation, invasiveness, and migratory capacity in dermal fibroblasts. Furthermore, METTL3-modified ASC-exos derived from METTL3-increased ASCs exerted more significantly promoting effects on fibroblast proliferation and migration than ASC-exos. Mechanistically, METTL3 upregulated CCNB1 by affecting its mRNA m6A modification. Additionally, reduction of CCNB1 had a counteracting impact on the effects of METTL3-modified ASC-exos in dermal fibroblasts. Our study shows that METTL3-modified ASC-exos enhance the migration and invasion of dermal fibroblasts by mediating CCNB1 mRNA m6A modification, raising hopes that these exosomes might serve as a therapeutic option for scalded skin wound repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.