Observational studyEuropean journal of nutrition2025
Maternal obesity, age and infant sex influence the profiles of amino acids, energetic metabolites, sugars, and fatty acids in human milk.
Observational study in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Sugar reduction in complex food systems: linking metabolic mechanisms, matrix engineering, and safety evaluation.NPJ science of food · 2026Review
- Maternal exercise during lactation remodels obesity-associated mammary metabolism and milk fatty acids, enhancing offspring lipid oxidation.American journal of physiology. Endocrinology and metabolism · 2026Article
- Metabolic reprogramming in placenta and umbilical cord serum of polycystic ovary syndrome pregnancies: testosterone-associated alterations and interaction with obesity.Human reproduction open · 2026Article
- Unraveling Stage-Specific Metabolites in Human Milk and Their Links to Maternal Physiology: Insights from a Mexican Population.Nutrients · 2025Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
purposeThis study aimed to evaluate whether maternal nutritional status, maternal age, mode of delivery, and the infant's sex influence the profiles of amino acids, energetic metabolites, sugars, and fatty acids and as well as the metabolic pathways in mature human milk human milk (HM).
methodsThis was a cross-sectional, prospective, and observational study. HM samples from normal weight (NW, n = 60), overweight (OW, n = 35), and obese (OB, n = 14) women were analyzed using a non-targeted GC-MS method to identify the metabolome. Data obtained were analyzed with Metaboanalyst software (v. 5.0) and SPSS (v.25.0).
resultsOB women HM contains a higher proportion of amino acids such as leucine, lysine, tyrosine, and aspartic acid, energy metabolites such as lactic and succinic acid, and sugars and derivatives such as fucose, rhamnose, and gluconic acid (p < 0.05) compared with normal weight women HM. HM from women > 25 years of age contains a lower proportion of lauric acid and a higher proportion of leucine and tyrosine (p < 0.05) than ≤ 25 years women HM. Also, HM intended for female infants has a higher leucine and gluconic acid content. The main altered metabolic pathways in OB women HM correspond to amino acids and energetic metabolism.
conclusionOB women HM provides more amino acids, energetic molecules, and sugars. Increased maternal weight, BMI, and body fat mass predispose to more leucine and aspartic acid in HM. Maternal age influences lauric acid, leucin, and tyrosine levels, while the infant's sex influences leucine and gluconic acid levels in HM. The impact of obese women's HM metabolome on the offspring's physiology needs to be explored.
trial registrationR-2021-785-096.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.