ArticleJournal of neural transmission (Vienna, Austria : 1996)2025
Severity of anhedonia is associated with hyper-synchronization of the salience-default mode network in non-clinical individuals: a resting state EEG connectivity study.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Born to act: Deferred action and desire as active inference.Cognitive, affective & behavioral neuroscience · 2025Review
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7 authors.
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Abstract
Anhedonia is a core transnosographic symptom in several neuropsychiatric disorders. Recently, the Triple Network (TN) model has been proposed as a useful neurophysiological paradigm for conceptualizing anhedonia, providing new insights to clinicians and researchers. Despite this, the relationship between the functional dynamics of TN and the severity of anhedonia has been relatively understudied in non-clinical samples, especially in the resting state (RS) condition. Therefore, in the current study, we investigated this relationship using electroencephalography (EEG) functional connectivity. Eighty-two participants (36 males; mean age: 24.28 ± 7.35 years) underwent RS EEG recording with eyes-closed and completed the Beck Depression Inventory-derived 4-item anhedonia scale (BDI-Anh4) and the Brief Symptoms Inventory (BSI). EEG data on functional connectivity were analyzed using the exact low-resolution electromagnetic tomography (eLORETA). A significant positive correlation was observed between the BDI-Anh4 total score and salience-default mode network connectivity in the beta frequency band (r = 0.409; p = 0.010). The results of the hierarchical linear regression analysis also showed that this connectivity pattern was positively and independently associated (β = 0.358; p < 0.001) with the BDI-Anh4 total score and explained an additional 11% of the anhedonia variability. The association between anhedonia severity and increased salience-default mode network synchronization detected in the current study may reflect difficulty disengaging from internal/self-related mental contents, which consequently impairs the processing of other stimuli, including rewarding stimuli.
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