Evidence map›Paper›PMID 39954024›Full record

ArticleJournal of gastrointestinal cancer2025

The Impact of Radiation Proctopathy on Secondary-Primary Colorectal Cancer in Patients with Prostate Cancer.

Akram I Ahmad, Zaid Ansari, Tasneem Jamal Al-Din, Ritu Channagiri, Osama Sherjeel Khan, Fernando J Castro

Abstract read
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Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Akram I AhmadDepartment of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA. ahmada5@ccf.org.
Zaid AnsariDepartment of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA.
Tasneem Jamal Al-DinDepartment of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA.
Ritu ChannagiriCollege of Medicine, Florida Atlantic University Charles E. Schmidt, Boca Raton, FL, 33431, USA.
Osama Sherjeel KhanDepartment of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA.
Fernando J CastroDepartment of Gastroenterology and Hepatology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL, 33331, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe designed this study to evaluate the relationship between radiation proctopathy (RP) and the risk of colon and rectal cancer in prostate cancer patients.

methodsThis is a retrospective cohort study evaluating patients with prostate cancer who received pelvic radiation therapy between January 2004 and January 2024. The study aims to compare the incidence of post-radiation rectal and colon cancer between patients who developed RP and patients who did not. We excluded patients with a previous history of colon cancer, colectomy, or inflammatory bowel disease.

resultsIn total, 12,629 met the inclusion criteria, 533 patients were diagnosed with RP, and 12,096 were without. We observed a higher incidence of colorectal cancer (3.75% vs. 0.63%), colon cancer (2.06% vs 0.40%), and rectal cancer (1.69% vs 0.23%) in patients with RP compared to those without PR (p < 0.001) during the follow-up period of 81 months for the RP group and 68 months for the non-RP group. PR was associated with colon and rectal cancer with an HR of 4.43 (95% CI, 2.29-8.57; p < 0.0001) and 7.27 (95% CI, 3.43-15.43; p < 0.0001), respectively.

conclusionsRP is an independent risk factor for developing rectal and colon cancer after pelvic radiation therapy in patients with prostate cancer.

Indexed as

Colorectal NeoplasmsNeoplasms, Radiation-InducedNeoplasms, Second PrimaryProstatic NeoplasmsRadiation InjuriesAgedAged, 80 and overFollow-Up StudiesHumansIncidenceMaleMiddle AgedRetrospective StudiesRisk FactorsColon cancerProctitisProstate cancerRadiation proctopathyRectal cancer

Identifiers

PMID39954024
PMCPMC11829924

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.