ArticleAngewandte Chemie (International ed. in English)2025
Pyridoxal-Inspired Photo-Decarboxylase Catalysis: Photochemical Decarboxylation of Unprotected Amino Acids.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
A photochemical organocatalytic method for the protodecarboxylation of unprotected amino acids is reported. Inspired by pyridoxal 5'-phosphate-dependent decarboxylase enzymes, the catalytic activation of amino acid substrates by 3-hydroxyisonicotinaldehyde enables a photochemical decarboxylation event, which can be leveraged in combination with a thiol co-catalyst. The necessary and sufficient structural features of the pyridoxal-like framework for photoactivity are determined using ultraviolet-visible absorption spectroscopy. A broad scope of unprotected amino acids can be decarboxylated in this system, with selectivity between multiple carboxylates realized on the possible basis of hyperconjugation. The ability to engage simple amino acids in decarboxylative functionalization at ambient conditions using a pyridoxal-mimicking organocatalyst enables new possibilities for the translation of biogenic amino acids into medicinally valuable amines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.