Evidence map›Paper›PMID 39953830›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Metabolism-inspired chemical reaction networks for chemically driven dissipative oligoesterification.

Yeonsoo Lim, Gyunam Park, Hojin An, Jonghwa Han, Joonhyun Bae, Ji-Hyun Kim, Yan Lee, Kyungtae Kang, Jaeyoung Sung, Sunbum Kwon

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yeonsoo LimDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0009-0002-6533-3239
Gyunam ParkDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0009-0007-8973-667X
Hojin AnDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0009-0006-7584-6483
Jonghwa HanDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0009-0002-9213-7268
Joonhyun BaeDepartment of Applied Chemistry, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Republic of Korea.ORCID https://orcid.org/0009-0001-7196-9690
Ji-Hyun KimDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0000-0003-1535-7224
Yan LeeDepartment of Chemistry, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.ORCID https://orcid.org/0000-0003-2498-1301
Kyungtae KangDepartment of Applied Chemistry, Kyung Hee University, 1732 Deogyeong-daero, Giheung-gu, Yongin, Republic of Korea.ORCID https://orcid.org/0000-0003-4236-8922
Jaeyoung SungDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0000-0003-0712-296X
Sunbum KwonDepartment of Chemistry, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, Republic of Korea.ORCID https://orcid.org/0000-0003-0027-6990

Funding

Chung-Ang University Graduate Research Scholarship 2018National Research Foundation of Korea RS-2023-00217942National Research Foundation of Korea RS-2024-00411134
6 · The paper itself

Abstract

Metabolism is a complex network of chemical reactions in which transient biomolecules are continuously produced and degraded. Mimicking this dynamic process in synthetic systems poses a considerable challenge, as it requires designs that enable the exchange of energy and matter among transient molecules. In this study, we explored a chemically driven oligoesterification process operating within a highly intricate reaction network and constructed a dynamic library of transient oligoesters. Our kinetic analysis uncovered an intriguing phenomenon: oligoesters undergo parasitic exchanges, consuming one another to sustain the system's dynamics before reaching thermodynamic equilibrium. This discovery opens new opportunities for designing synthetic systems that replicate the complexity and self-sustaining behavior of metabolic processes.

Indexed as

chemical reaction networkmetabolismoligoesterOut-of-equilibrium systemsreaction kinetics

Identifiers

PMID39953830
PMCPMC11966691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.