Evidence map›Paper›PMID 39953814›Full record

ArticleJournal of viral hepatitis2025

Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B.

Hee-Soon Juon, Daniel Yang, Cindy Xin Fang, Hie-Won Hann, Ho Bae, Mimi Chang, Ann C Klassen

Abstract read
In one paragraph

Article in Journal of viral hepatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hee-Soon JuonDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-7837-7009
Daniel YangDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Cindy Xin FangDepartment of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Hie-Won HannLiver Disease Prevention Center, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Ho BaeAsian Pacific Liver Center, Coalition of Inclusive Medicine, Los Angeles, California, USA.
Mimi ChangAsian Pacific Liver Center, Coalition of Inclusive Medicine, Los Angeles, California, USA.
Ann C KlassenDornsife School of Public Health, Drexel University, Philadelphia, Pennsylvania, USA.

Funding

Bio-Psycho-Social Drivers of Disparities in Liver Disease Progression among Korean Americans with Hepatitis B InfectionR01DK125541 · NIDDK · THOMAS JEFFERSON UNIVERSITY · PI JUON, HEE-SOON, KLASSEN, ANN CARROLL · 2021 to 2024
$2.6M
NIDDK NIH HHS R01 DK125541NIH HHS R01DK125541
6 · The paper itself

Abstract

Medication nonadherence among patients with chronic hepatitis B (CHB) can lead to severe liver disease progression, including liver cirrhosis and hepatocellular carcinoma (HCC). Yet the factors that influence adherence in high-risk groups, like Korean Americans, remain unclear. Thus, this study explored the psychosocial and clinical factors affecting medication adherence in CHB patients. A cohort of 365 Korean American patients with CHB from two clinics in Philadelphia and Los Angeles was studied. The 8-item Morisky Medication Adherence Scale (MMAS-8) gauged their adherence to antiviral medication. Using descriptive and multivariable logistic regression analyses, we identified factors associated with MMAS-8 scores. Of the participants, 78% were undergoing antiviral therapy, with over two-thirds (69%) reporting medium to high adherence levels. The multivariable logistic regression analysis revealed that age, knowledge of sequalae of CHB, perceived HBV stigma and possession of pharmacy plan were associated with medication adherence. Older participants had higher medication adherence than younger. High knowledge of sequalae of CHB and low perceived HBV stigma were associated with higher medication adherence. Having pharmacy plans was also associated with higher medication adherence to antiviral therapy. These findings highlight the critical role of person-related factors (e.g., knowledge and stigma) and healthcare factors in medication adherence. Future research should focus on developing targeted educational interventions focusing on personal factors to improve medication adherence among Korean American patients with CHB.

Indexed as

Antiviral AgentsHepatitis B, ChronicMedication AdherenceSocial StigmaAdultAgedAsianFemaleHumansLos AngelesMaleMiddle AgedAntiviral AgentsAsian AmericansCHB patientsKorean Americansmedication adherenceMMAS‐8

Identifiers

PMID39953814
PMCPMC11829210

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.