Evidence map›Paper›PMID 39953812›Full record

ArticleCNS neuroscience & therapeutics2025

Integration of Methylation and Gene Expression Deciphered Candidate Biomarkers DAB2IP and SMYD3 in Delayed Encephalopathy After Carbon Monoxide Poisoning.

Hongyi Yan, Ding Yuan, Yan Zhang, Haihua Luo, Pinpin Jiang, Yapeng Zhang, Yue Wu, Linlin Hou, Yue Cheng, Fang Yang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hongyi YanDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.ORCID 0000-0003-4185-0506
Ding YuanDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Yan ZhangDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Haihua LuoState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Pinpin JiangDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Yapeng ZhangDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Yue WuDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Linlin HouDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Yue ChengDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Fang YangDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Yuqi DuDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Huanzhou ZhuDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.
Linshuang ZhaoSchool of Pharmacy, Fudan University, Shanghai, China.
Yi LiEmergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.ORCID 0000-0002-7158-3624
Yong JiangState Key Laboratory of Antiviral Drugs, Henan Key Laboratory of Critical Care Medicine, Henan International Joint Laboratory of Infection and Immunology, Department of Emergency Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.
Yanxia GaoDepartment of Emergency Medicine, The First Affiliated Hospital of Zhengzhou University, Medical Key Laboratory of Poisoning Diseases of Henan Province, Zhengzhou, China.

Funding

Intramural Innovation Team Program from The First Affiliated Hospital of Zhengzhou University QNCXTD2023004Key Scientific of Colleges and Universities in Henan Province 23A320009Key Scientific of Colleges and Universities in Henan Province 24A320025National Natural Science Foundation of China 82172180National Natural Science Foundation of China 82302483National Natural Science Foundation of China 82372215Peking Union Medical Foundation - Rui E (Rui Yi) Emergency Medical Research Special Fund R2020014
6 · The paper itself

Abstract

aimsThe objective of this study is to explore the regulatory role of DNA methylation in delayed encephalopathy after carbon monoxide poisoning (DEACMP) and to identify candidate epigenetic biomarkers.

methodsIn this study, multi-omics analyses such as methylomics, transcriptomics, pyrophosphate sequencing, qRT-PCR, immunohistochemistry, and western blotting were utilized to investigate the role of epigenetic regulation and altered gene expression in the pathogenesis of DEACMP.

resultsUsing integrated analysis, we identified 168 differentially methylated CpGs sites, 334 differentially expressed genes, and two differentially methylated and differentially expressed genes (DAB2IP and SMYD3) in the DEACMP group. The pyrosequencing results further revealed hypomethylation of DAB2IP and hypermethylation of SMYD3. Moreover, we verified the upregulation of DAB2IP expression accompanied by the downregulation of SMYD3 expression in the DEACMP rats model.

conclusionThis study, based on dysregulated DNA methylation and gene expression profiles, identified and validated two DEACMP-related genes (DAB2IP and SMYD3) that could serve as epigenetic biomarkers and potential therapeutic targets for DEACMP.

Indexed as

Brain DiseasesCarbon Monoxide PoisoningDNA MethylationHistone-Lysine N-MethyltransferaseAnimalsBiomarkersDisease Models, AnimalEpigenesis, GeneticMaleRatsRats, Sprague-DawleyBiomarkersHistone-Lysine N-Methyltransferasedelayed encephalopathy after carbon monoxide poisoningDNA methylationepigenetic biomarkerpyrosequencingRNA sequencing

Identifiers

PMID39953812
PMCPMC11829117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.